1-BOC-BETA-OXO-2-PYRROLIDINEPROPANOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 1-BOC-BETA-OXO-2-PYRROLIDINEPROPANOIC ACID ETHYL ESTER
• CAS No.: 108310-01-6
• Molecular Formula: C₁₄H₂₃NO₅
• Molecular Weight: 285.34
• Mol file: 108310-01-6.mol

Synonyms:1-BOC-BETA-OXO-2-PYRROLIDINEPROPANOIC ACID ETHYL ESTER;Ethyl 1-Boc-b-oxo-2-pyrrolidinepropanoate;Ethyl 1-[(1,1-dimethylethoxy)carbonyl]-beta-oxo-2-pyrrolidinepropanoate

Chemical Property of 1-BOC-BETA-OXO-2-PYRROLIDINEPROPANOIC ACID ETHYL ESTER

Chemical Property:

• PSA: 72.91000
• LogP: 1.84610

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1-Boc-b-oxo-2-pyrrolidinepropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-BETA-OXO-2-PYRROLIDINEPROPANOIC ACID ETHYL ESTER

There total 10 articles about 1-BOC-BETA-OXO-2-PYRROLIDINEPROPANOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (2S)-2-[(2,2-dimethyl-4,6-oxo-1,3-dioxan-5-yl)carbonyl]-1-pyrrolidinecarboxylate (603998-95-4) + ethanol (64-17-5) → (S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (109180-95-2,108310-01-6)

Guidance literature:

for 3h; Heating / reflux;

Reference yield: 80.0%

diazoacetic acid ethyl ester (623-73-4) + Boc-L-Pro-H (69610-41-9,117625-90-8) → (S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (109180-95-2,108310-01-6)

Guidance literature:

With tin(ll) chloride; In dichloromethane;

DOI:10.1021/ol403290h

Reference yield: 66.0%

ethyl potassium malonate (6148-64-7) + (S) tert-butyl 2-(1H-imidazole-1-carbonyl)pyrrolidine-1-carboxylate (115655-70-4) → (S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (109180-95-2,108310-01-6)

Guidance literature:

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃; for 6h; Inert atmosphere;

(S) tert-butyl 2-(1H-imidazole-1-carbonyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; at 20 ℃; for 20.3333h; Inert atmosphere;

upstream raw materials:

ethyl lithioacetate

Boc-L-Pro-H

(S)-N-(tert-butoxycarbonyl)proline methyl ester

tert-butyl (2S)-2-[(2,2-dimethyl-4,6-oxo-1,3-dioxan-5-yl)carbonyl]-1-pyrrolidinecarboxylate

Downstream raw materials:

(7aS)-p-hydroxyphenopyrrozin

C₂₀H₂₉NO₄

C₂₀H₂₇NO₄

C₂₀H₂₇NO₅