4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester

Base Information

Chemical Name:4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester
CAS No.:1313441-88-1
Molecular Formula:C20H32BNO5
Molecular Weight:359.273
Hs Code.:
Mol file:1313441-88-1.mol

Synonyms:4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester

Suppliers and Price of 4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[1-(N-Boc-amino)cyclopropyl]phenylboronicAcidPinacolEster
250mg
$ 290.00

TRC
4-[1-(N-Boc-amino)cyclopropyl]phenylboronicAcidPinacolEster
100mg
$ 165.00

TRC
4-[1-(N-Boc-amino)cyclopropyl]phenylboronicAcidPinacolEster
50mg
$ 105.00

Crysdot
tert-Butyl(1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)carbamate 95+%
1g
$ 395.00

AK Scientific
4-[1-(N-BOC-Amino)cyclopropyl]phenylboronicacidpinacolester
1g
$ 611.00

Total 6 raw suppliers

Chemical Property of 4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester

Chemical Property:

PSA：56.79000
LogP:3.89050

Purity/Quality:

97% ^*data from raw suppliers

4-[1-(N-Boc-amino)cyclopropyl]phenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-[1-(N-Boc-amino)cyclopropyl]phenylboronic Acid Pinacol Ester is used in the synthesis of fused pyridine compounds for inhibiting serine-threonine kinase AKT and for treating cancer.

Technology Process of 4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester

There total 3 articles about 4-[1-(N-BOC-AMino)cyclopropyl]phenylboronic acid, pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 360773-84-8
tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate

: 73183-34-3
bis(pinacol)diborane

: 1313441-88-1
tert-butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 70 ℃; for 12h; Inert atmosphere;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1313441-88-1
tert-butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 20 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 100 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 345965-54-0
1-(4-bromophenyl)-cyclopropylamine

: 1313441-88-1
tert-butyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 20 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / N,N-dimethyl-formamide / 100 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; sodium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;