methyl 3-bromo-5-fluoro-4-hydroxybenzoate

Base Information

• Chemical Name: methyl 3-bromo-5-fluoro-4-hydroxybenzoate
• CAS No.: 445019-48-7
• Molecular Formula: C₈H₆BrFO₃
• Molecular Weight: 249.036
• Hs Code.: 2918290090
• Mol file: 445019-48-7.mol

Synonyms:methyl 3-bromo-5-fluoro-4-hydroxybenzoate

Chemical Property of methyl 3-bromo-5-fluoro-4-hydroxybenzoate

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Methyl 3-bromo-5-fluoro-4-hydroxybenzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-bromo-5-fluoro-4-hydroxybenzoate

There total 2 articles about methyl 3-bromo-5-fluoro-4-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-fluoro-4-hydroxybenzoate (403-01-0) → methyl 5-bromo-3-fluoro-4-hydroxybenzoate (445019-48-7)

Guidance literature:

With bromine; acetic acid; In dichloromethane; at 20 ℃; Ice cooled;

Reference yield:

3-fluoro-4-hydroxybenzoic acid (350-29-8) → methyl 5-bromo-3-fluoro-4-hydroxybenzoate (445019-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 18 h / 0 - 65 °C

2: bromine / acetic acid; dichloromethane / 48.5 h / 0 - 20 °C

With thionyl chloride; bromine; In dichloromethane; acetic acid;

Reference yield:

sodium chlorodifluoroacetate (1895-39-2) + methyl 5-bromo-3-fluoro-4-hydroxybenzoate (445019-48-7) → methyl 3-bromo-4-(difluoromethoxy)-5-fluorobenzoate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

upstream raw materials:

methyl 3-fluoro-4-hydroxybenzoate

3-fluoro-4-hydroxybenzoic acid

Downstream raw materials:

methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-hydroxybenzoate

methyl 3-(5,5-dimethyl-1-cyclopenten-1-yl)-5-fluoro-4-(((trifluoromethyl)sulfonyl)oxy)benzoate

methyl 2-(5,5-dimethyl-1-cyclopenten-1-yl)-2',6-difluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

methyl 3-(5,5-dimethyI-1-cyclopenten-1-yl)-5-fluoro-4-(((4-(methyloxy)phenyl)methyl)oxy)benzoate

Refernces

• 1、 -. "1,2,3,5-TETRAHYDROIMIDAZO[1,2-C]PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF DISEASES AND DISORDERS MEDIATED BY LP-PLA2". Page/Page column 40; 41. . Retrieved 2016/02/18.
• 2、 -. "CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS". Page/Page column 228. . Retrieved 2009/10/22.