6-(2,4-Difluorophenoxy)pyridin-3-amine

Base Information

Chemical Name:6-(2,4-Difluorophenoxy)pyridin-3-amine
CAS No.:219865-96-0
Molecular Formula:C11H6F2N2O3
Molecular Weight:222.194
Hs Code.:2933399090
European Community (EC) Number:851-122-3
DSSTox Substance ID:DTXSID70384142
Wikidata:Q82176093
Mol file:219865-96-0.mol

Synonyms:6-(2,4-difluorophenoxy)pyridin-3-amine;6-(2,4-Difluoro-phenoxy)-pyridin-3-ylamine;Maybridge1_001819;SCHEMBL15921050;HMS546K15;DTXSID70384142;YXBJKFLKYCEHCM-UHFFFAOYSA-N;AB3644;MFCD00067769;AKOS000138509;CCG-235587;SB79733;6-(2,4-difluorophenoxyl)pyridin-3-amine;6-(2,4-difluorophenoxy)pyridin-3-ylamine;EN300-85669;J-014396;6-(2,4-Difluorophenoxy)pyridin-3-amine, AldrichCPR;Z240084326

Suppliers and Price of 6-(2,4-Difluorophenoxy)pyridin-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Oakwood
6-(2,4-Difluoro-phenoxy)-pyridin-3-ylamine 95%
1g
$ 150.00

Crysdot
6-(2,4-Difluoro-phenoxy)-pyridin-3-ylamine 95+%
5g
$ 687.00

AK Scientific
6-(2,4-Difluorophenoxy)pyridin-3-amine
1g
$ 252.00

Total 2 raw suppliers

Chemical Property of 6-(2,4-Difluorophenoxy)pyridin-3-amine

Chemical Property:

PSA：67.94000
LogP:3.58350
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:222.06046921
Heavy Atom Count:16
Complexity:230

Purity/Quality:

97% ^*data from raw suppliers

6-(2,4-Difluoro-phenoxy)-pyridin-3-ylamine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)F)OC2=NC=C(C=C2)N

Technology Process of 6-(2,4-Difluorophenoxy)pyridin-3-amine

There total 2 articles about 6-(2,4-Difluorophenoxy)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 219865-86-8
2-(2,4-difluorophenoxy)-5-nitropyridine

: 219865-96-0
6-(2,4-difluorophenoxy)pyridine-3-amine

Guidance literature:: With sodium sulfate; In tetrahydrofuran; water; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2020.115990

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 367-27-1
2,4-difluorophenol

: 219865-96-0
6-(2,4-difluorophenoxy)pyridine-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: sodium sulfate / tetrahydrofuran; water / 2.5 h / 20 °C

With potassium carbonate; sodium sulfate; In tetrahydrofuran; water; acetone;
DOI:10.1016/j.bmc.2020.115990

Reference yield: 16.0%

: 219865-96-0
6-(2,4-difluorophenoxy)pyridine-3-amine

: 22131-51-7
5-amino-3-methyl-1,2-thiazole-4-carboxylic acid

: 1621367-93-8
5-amino-N-[6-(2,4-difluorophenoxy)pyridin-3-yl]-3-methyl-1,2-thiazole-4-carboxamide

Guidance literature:: 5-amino-3-methyl-1,2-thiazole-4-carboxylic acid; With thionyl chloride; at 80 ℃; for 5h;

6-(2,4-difluorophenoxy)pyridine-3-amine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2.75h;