(2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate

Base Information

Chemical Name:(2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate
CAS No.:1496551-70-2
Molecular Formula:C31H26ClN3O7
Molecular Weight:588.00704
Hs Code.:
Mol file:1496551-70-2.mol

Synonyms:(2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate

Suppliers and Price of (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-chloro-4-methyltetrahydrofuran-3-ylbenzoate
5mg
$ 1500.00

Total 12 raw suppliers

Chemical Property of (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate

Chemical Property:

PKA:8.52±0.20(Predicted)
Density:1.36±0.1 g/cm3(Predicted)

Purity/Quality:

NLT 98% ^*data from raw suppliers

(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-chloro-4-methyltetrahydrofuran-3-ylbenzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate

There total 7 articles about (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 26661-13-2
4-N-benzoylcytosine

: C₂₀H₁₈BrClO₅

: 1496551-70-2
2'-deoxy-2'-chloro-2'-C-methyl-3',5'-di-O-benzoyl-N⁴-benzoylcytidine

Guidance literature:: With tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In chlorobenzene; at 70 ℃;
DOI:10.1016/j.bmcl.2017.08.029

Reference yield: 44.6%

: 1-O-acetyl-2-deoxy-2-chloro-3,5-di-O-benzoyl-2-C-methyl-α/β-D-ribofuranose

: 238096-55-4
N-(2-((1-trimethylsilyl)oxy)pyrimidin-4-yl)benzamide

: 1496551-70-2
2'-deoxy-2'-chloro-2'-C-methyl-3',5'-di-O-benzoyl-N⁴-benzoylcytidine

Guidance literature:: With tin(IV) chloride; In chlorobenzene; at 20 - 70 ℃;
DOI:10.1021/acs.jmedchem.9b00143

Reference yield:

: 879551-01-6
(4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide

: 1496551-70-2
2'-deoxy-2'-chloro-2'-C-methyl-3',5'-di-O-benzoyl-N⁴-benzoylcytidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl-ammonium chloride / 1,4-dioxane / 120 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / ethanol / 48 h / 20 °C

3.1: pyridine / 0.75 h / 0 - 20 °C

4.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 3 h / -60 °C / Inert atmosphere

4.2: 1 h / 0 - 5 °C

5.1: tin(IV) chloride / chlorobenzene / 20 - 70 °C

With pyridine; hydrogenchloride; tetrabutyl-ammonium chloride; tin(IV) chloride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; 1,4-dioxane; ethanol; chlorobenzene;
DOI:10.1021/acs.jmedchem.9b00143