207691-65-4

Basic information

• Product Name: 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE
• Synonyms: 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE;tert-butyl 4-(pyrrolidin-1-yl)-5,6-dihydropyridine-1(2H)-carboxylate;tert-butyl 4-(pyrrolidin-1-yl)-3,6-dihydropyridine-1(2H)-carboxylate;4-Pyrrolidin-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
• CAS NO: 207691-65-4
• Molecular Formula: C₁₄H₂₄N₂O₂
• Molecular Weight: 252.35
• Product Categories: pharmacetical
• Mol File: 207691-65-4.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 359.1°Cat760mmHg
• Flash Point: 171°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 2.43E-05mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• PKA: 7.87±0.20(Predicted)
• CAS DataBase Reference: 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE(207691-65-4)
• EPA Substance Registry System: 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE(207691-65-4)

Safety Data

• Hazardous Substances Data: 207691-65-4(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(1-Pyrrolidinyl)-3,6-dihydro-2H-pyridine, also known as Boc-pyrrolidinylpyridine, is a chemical compound with the molecular formula C15H23NO2. It is a derivative of pyridine and contains a Boc (tert-butoxycarbonyl) protecting group and a pyrrolidinyl substituent. 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE is commonly used in organic synthesis as a building block for the preparation of various pharmaceutical and biologically active molecules. It is often used as an intermediate in the synthesis of drugs and other complex organic compounds due to its reactivity and versatility. Additionally, it has been investigated for its potential pharmacological properties and applications in drug discovery and development.

InChI:InChI=1/C14H24N2O2/c1-14(2,3)18-13(17)16-10-6-12(7-11-16)15-8-4-5-9-15/h6H,4-5,7-11H2,1-3H3

Upstream product

• 123-75-1 pyrrolidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 1149333-40-3 2-amino-7,8-dihydro-1,6-naphthyridin-6(5H)-carboxylic acid tert-butyl ester 
• 1038992-90-3 tert-butyl 3-[3-(benzyloxy)-3-oxopropyl]-4-oxopiperidine-1-carboxylate 
• 848410-30-0 1-benzyl-octahydro-[1,6]naphthyridin-2-one; hydrochloride 
• 946620-02-6 C₄₁H₃₉F₄N₉O₅S 
• 951632-03-4 C₄₇H₅₃F₄N₉O₆SSi 
• 946620-01-5 C₄₂H₄₀F₄N₈O₅S 
• 951631-49-5 C₄₈H₅₄F₄N₈O₆SSi 
• 946620-00-4 C₄₁H₃₈F₅N₇O₅S 
• 951631-18-8 C₄₇H₅₂F₅N₇O₆SSi 
• 946619-99-4 C₄₀H₃₈F₄N₈O₅S 
• 946619-78-9 C₁₇H₁₇F₃N₂O 
• 951631-17-7 C₄₆H₅₂F₄N₈O₆SSi 
• 946619-98-3 C₄₁H₃₉F₄N₇O₅S 

Relevant articles and documents

Synthesis of 3-azabicyclo[3.3.1]Nonane-6,9-diones

A one pot synthesis of 3-azabicyclo[3.3.1]nonane-6,9-diones is described via the additibn of acryloyl chloride to enamines of N-carboxy-4 piperidones. Yields of bicycle were highest when additions were made to vigorously boiling solutions of morpholine en

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin)

Pendrin is a transmembrane chloride/anion antiporter that is strongly upregulated in the airways in rhinoviral infection, asthma, cystic fibrosis and chronic rhinosinusitis. Based on its role in the regulation of airway surface liquid depth, pendrin inhibitors have potential indications for treatment of inflammatory airways diseases. Here, a completely regioselective route to tetrahydro-pyrazolopyridine pendrin inhibitors based on 1,3-diketone and substituted hydrazine condensation was been developed. Structure-activity relationships at the tetrahydropyridyl nitrogen were investigated using a focused library, establishing the privileged nature of N-phenyl ureas and improving inhibitor potency by greater than 2-fold.