207691-65-4

Usage

Uses

Used in Pharmaceutical Industry:
1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE is used as a key intermediate in the synthesis of drugs and other complex organic compounds. Its role is crucial for the development of new pharmaceuticals due to its ability to be incorporated into the molecular structures of potential therapeutic agents, enhancing their pharmacological properties and efficacy.
Used in Organic Synthesis:
In the field of organic synthesis, 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE serves as a versatile building block. It is utilized for the preparation of a wide range of biologically active molecules, contributing to the discovery and development of new chemical entities with potential applications in medicine and other areas.
Used in Drug Discovery and Development:
1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE is also investigated for its intrinsic pharmacological properties, making it a subject of interest in drug discovery and development. Its unique structure and functional groups may endow it with specific biological activities that could be harnessed in the creation of novel therapeutic agents.
Overall, 1-BOC-4-(1-PYRROLIDINYL)-3,6-DIHYDRO-2H-PYRIDINE is a significant compound in the realm of chemistry and pharmaceuticals, with its applications spanning across various stages of drug development, from synthesis to potential direct therapeutic use.

InChI:InChI=1/C14H24N2O2/c1-14(2,3)18-13(17)16-10-6-12(7-11-16)15-8-4-5-9-15/h6H,4-5,7-11H2,1-3H3

Upstream product

• 123-75-1 pyrrolidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 946619-77-8 C₂₀H₂₆N₂O₂ 
• 1038992-90-3 tert-butyl 3-[3-(benzyloxy)-3-oxopropyl]-4-oxopiperidine-1-carboxylate 
• 694450-89-0 C₁₃H₂₁NO₅ 
• 1323999-43-4 C₁₇H₃₀N₂O₄ 
• 1149333-40-3 2-amino-7,8-dihydro-1,6-naphthyridin-6(5H)-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of 3-azabicyclo[3.3.1]Nonane-6,9-diones

A one pot synthesis of 3-azabicyclo[3.3.1]nonane-6,9-diones is described via the additibn of acryloyl chloride to enamines of N-carboxy-4 piperidones. Yields of bicycle were highest when additions were made to vigorously boiling solutions of morpholine en

FUSED PYRAZOLE AND IMIDAZOLE BASED COMPOUNDS AND USE THEREOF AS GLI1 INHIBITORS

The present invention is directed to a composition and a method for use thereof, such as for the treatment and prevention of a neurological disorder or cancer in a subject.

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

NOVEL DIHYDROISOXAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HEPATITIS B

PAT057954-WO-PCT ABSTRACT The invention provides compounds of Formula (I) n R3b Z W Q R3a H Y N R1 R4 R2 O (I) as described herein, along with stereoisomeric forms salts, hydrates, solvates, and salts thereof and pharmaceutical compositions and pharmaceut

Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin)

Pendrin is a transmembrane chloride/anion antiporter that is strongly upregulated in the airways in rhinoviral infection, asthma, cystic fibrosis and chronic rhinosinusitis. Based on its role in the regulation of airway surface liquid depth, pendrin inhibitors have potential indications for treatment of inflammatory airways diseases. Here, a completely regioselective route to tetrahydro-pyrazolopyridine pendrin inhibitors based on 1,3-diketone and substituted hydrazine condensation was been developed. Structure-activity relationships at the tetrahydropyridyl nitrogen were investigated using a focused library, establishing the privileged nature of N-phenyl ureas and improving inhibitor potency by greater than 2-fold.

Inhibiting effect of trisubstituted pyrimidine derivative on protein kinase

The invention discloses a trisubstituted pyrimidine derivative with a structure shown as general formula (I), and pharmaceutically acceptable salt, ester or solvent compound thereof. The derivative isa protein kinase inhibitor, can be used individually or in combination with other drugs for cancer treatment, and has tremendous clinical application value. General formula (I) is shown as the specification.

Design and synthesis of a fragment set based on twisted bicyclic lactams

Current fragment sets tend to be dominated by flatter molecules, and their shape diversity does not reflect that of the fragments that are theoretically possible. The design and synthesis of a set of bridged fragments containing a bridgehead nitrogen is d

Substituted amide compound and application

The invention belongs to the field of agricultural bactericidal, insecticidal and acaricidal agents, and relates to a substituted amide compound and an application. The substituted amide compound has a structure as shown in a general formula I in the specification; and in the general formula I, substituents are defined in the specification. The compound provided by the invention has broad-spectrum bactericidal, insecticidal and acaricidal activities, has excellent control effects on diseases like cucumber downy mildew, corn rust, wheat powdery mildew and rice blast, especially has better control effects on the corn rust, also has excellent control effects on aphids and Tetranychus cinnabarinus, and especially can obtain good effects on the Tetranychus cinnabarinus at a low dosage.

Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent

A novel chemical reagent – difluoromethyl nitrile oxide, CF2HCNO – was generated in situ for the first time. The synthesis commenced with ethyl difluoroacetate and included only two chemical steps. The difluoromethyl nitrile oxide smoothly participated in [3+2]-cycloaddition reactions with alkynes and enamines to give CF2H-isoxazoles; these products are promising cores for agrochemistry. A representative CHF2-isoxazole was incorporated into the known fungicide Fluxapyroxad (BASF), and the synthesized analogue showed higher antifungal activity than the parent fungicide.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.