5-Methyl-2'-deoxy Cytidine-d3

Base Information

• Chemical Name: 5-Methyl-2'-deoxy Cytidine-d3
• CAS No.: 1160707-78-7
• Molecular Formula: C10H12D3N3O4
• Molecular Weight: 244.223
• Mol file: 1160707-78-7.mol

Synonyms:5-Methyl-2'-deoxy Cytidine-d3;2'-Deoxy-5-(Methyl-d3)cytidine

Chemical Property of 5-Methyl-2'-deoxy Cytidine-d3

Chemical Property:

• Melting Point: 192-195?C
• PSA: 111.59000
• LogP: -0.92550
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

5-Methyl-2’-deoxyCytidine-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled Cytidine (C998300) analog and also an isostere of Thymidine (T412000).

Technology Process of 5-Methyl-2'-deoxy Cytidine-d3

There total 1 articles about 5-Methyl-2'-deoxy Cytidine-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

methyl-d3-magnesium iodide (41251-37-0) + 5-iodo-3'O,5'O-bis(tert-butyldimethylsilyl)-2'-deoxycytidine (478843-96-8) → 5-trideuteriomethyl-2'-deoxycytidine (1160707-78-7)

Guidance literature:

methyl-d3-magnesium iodide; 5-iodo-3'O,5'O-bis(tert-butyldimethylsilyl)-2'-deoxycytidine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; In tetrahydrofuran; diethyl ether; at 0 ℃;

With pyridine; pyridine hydrofluoride; In ethyl acetate;

DOI:10.1002/anie.201002033

upstream raw materials:

methyl-d3-magnesium iodide

5-iodo-3'O,5'O-bis(tert-butyldimethylsilyl)-2'-deoxycytidine

Refernces