N-Trityl Losartan Carboxylic Acid

Base Information

• Chemical Name: N-Trityl Losartan Carboxylic Acid
• CAS No.: 947331-10-4
• Molecular Formula: C41H35ClN6O2
• Molecular Weight: 679.221
• Mol file: 947331-10-4.mol

Synonyms:2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Aci;N-Trityl Losartan Carboxylic Acid;2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid

Chemical Property of N-Trityl Losartan Carboxylic Acid

Chemical Property:

• Vapor Pressure: 9.31E-33mmHg at 25°C
• Boiling Point: 875.2°C at 760 mmHg
• Flash Point: 483.1°C
• Density: 1.25g/cm³

Purity/Quality:

97% ^*data from raw suppliers

N-TRITYL LOSARTAN CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A Losartan derivative for treatment of hypertension

Technology Process of N-Trityl Losartan Carboxylic Acid

There total 3 articles about N-Trityl Losartan Carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) + 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid (124750-92-1) → 2-butyl-4-chloro-1-((2'-(2-trityl-2H-tetrazol-5-yl)[biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid (947331-10-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

cozaar (124750-99-8) → 2-butyl-4-chloro-1-((2'-(2-trityl-2H-tetrazol-5-yl)[biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid (947331-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium periodate; rhodium(III) chloride hydrate; potassium hydroxide / water / 0 °C

1.2: IPA / 25 °C

1.3: 30 °C

2.1: triethylamine / dichloromethane / 20 °C

With sodium periodate; rhodium(III) chloride hydrate; triethylamine; potassium hydroxide; In dichloromethane; water;

Reference yield:

lorsartan (114798-26-4) → 2-butyl-4-chloro-1-((2'-(2-trityl-2H-tetrazol-5-yl)[biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid (947331-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ruthenium(III) trichloride hydrate; sodium periodate; potassium hydroxide / water / 0 °C

2: triethylamine / dichloromethane / 20 °C

With sodium periodate; ruthenium(III) trichloride hydrate; triethylamine; potassium hydroxide; In dichloromethane; water;

upstream raw materials:

trityl chloride

2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid

lorsartan

cozaar

Downstream raw materials:

C₄₇H₄₅ClN₆O₅

C₄₈H₄₇ClN₆O₅

2-butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl) 1,1'-biphenyl-methyl]imidazole-5-carboxylic acid ethyl ester

2-butyl-4-chloro-1-[(2'-(1-triphenylmethyl-1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl]imidazole-5-carboxylic acid 1-[(isopropoxy)carbonyloxy]methyl ester

Refernces

• 1、 -. "RAAS system as a dual inhibitor compounds". Paragraph 0042; 0043; 0045. . Retrieved 2017/02/28.
• 2、 -. "ANGIOTENSIN II RECEPTOR ANTAGONISTS". Page/Page column 20. . Retrieved 2009/07/03.