N-(2,3-diMethylbenzyl)cyclopropanaMine

Base Information

• Chemical Name: N-(2,3-diMethylbenzyl)cyclopropanaMine
• CAS No.: 625437-38-9
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Hs Code.: 2921499090
• Mol file: 625437-38-9.mol

Synonyms:N-(2,3-diMethylbenzyl)cyclopropanaMine;N-(2,3-diMethylbenzyl)cyclopropanaMine hydrochloride;BenzeneMethanaMine, N-cyclopropyl-2,3-diMethyl-

Chemical Property of N-(2,3-diMethylbenzyl)cyclopropanaMine

Chemical Property:

• PSA: 12.03000
• LogP: 2.94630

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

N-(2,3-Dimethylbenzyl)cyclopropanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,3-diMethylbenzyl)cyclopropanaMine

There total 3 articles about N-(2,3-diMethylbenzyl)cyclopropanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3-dimethylbenzaldehyde (5779-93-1) + Cyclopropylamine (765-30-0) → cyclopropyl-(2,3-dimethyl-benzyl)-amine (625437-38-9)

Guidance literature:

2,3-dimethylbenzaldehyde; Cyclopropylamine; With sodium hydrogencarbonate; In methanol; at 67 ℃; for 0.5 - 4h; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 18h;

With water; In dichloromethane; Product distribution / selectivity;

Reference yield:

N-cyclopropyl-2,3-dimethylbenzamide (940774-65-2) → cyclopropyl-(2,3-dimethyl-benzyl)-amine (625437-38-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 60 ℃;

Reference yield:

2,3-dimethylbenzoic acid (603-79-2) → cyclopropyl-(2,3-dimethyl-benzyl)-amine (625437-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 60 °C

With dimethylsulfide borane complex; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2,3-dimethylbenzaldehyde

Cyclopropylamine

2,3-dimethylbenzoic acid

N-cyclopropyl-2,3-dimethylbenzamide

Downstream raw materials:

2-cyano-N-cyclopropyl-N-(2,3-dimethyl-benzyl)-acetamide

(3R,4S)-1-benzyl-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}pyrrolidine-3-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide

N-(2,3-dimethylbenzyl)cyclopropanamine hydrochloride

C₃₄H₃₉N₃O₄

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