3,6-dimethoxypyridazin-4-ylboronic acid

Base Information

• Chemical Name: 3,6-dimethoxypyridazin-4-ylboronic acid
• CAS No.: 1015480-87-1
• Molecular Formula: C4H4N2
• Molecular Weight: 183.959
• Hs Code.: 2933990090
• Mol file: 1015480-87-1.mol

Synonyms:1,2-Diazabenzene;o-diazine;Pyridazin;1,2-DIAZINE;AKOS 92457;ORTHODIAZINE;OIZINE;PYRIDAZINE

Chemical Property of 3,6-dimethoxypyridazin-4-ylboronic acid

Chemical Property:

• Melting Point: −8 °C(lit.)
• Boiling Point: 208 °C(lit.)
• Flash Point: 185 °F
• PSA: 84.70000
• Density: 1.103 g/mL at 25 °C(lit.)
• LogP: -1.82640
• Storage Temp.: 2-8°C

Purity/Quality:

95% purity ^*data from raw suppliers

3,6-Dimethoxypyridazine-4-boronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-dimethoxypyridazin-4-ylboronic acid

There total 1 articles about 3,6-dimethoxypyridazin-4-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3,6-dimethoxypyridazine (4603-59-2) → (3,6-dimethoxypyridazin-4-yl)boronic acid (1015480-87-1)

Guidance literature:

3,6-dimethoxypyridazine; With Triisopropyl borate; diisopropylamine; In tetrahydrofuran; at -70 - 3 ℃;

With water; In tetrahydrofuran; at -20 - 24 ℃;

With hydrogen bromide; In water; for 2h; pH=5 - 6;

Reference yield: 98.0%

(3,6-dimethoxypyridazin-4-yl)boronic acid (1015480-87-1) + C17H19BrO4 → C23H26N2O6

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115671

Reference yield: 70.0%

(3,6-dimethoxypyridazin-4-yl)boronic acid (1015480-87-1) + 3-bromo-N-[2-(3-fluorophenyl)-ethyl]-5-trifluoromethyl-benzenesulfonamide → 3-(3,6-dimethoxy-pyridazin-4-yl)-N-[2-(3-fluoro-phenyl)-ethyl]-5-trifluoromethyl-benzenesulfonamide

Guidance literature:

(3,6-dimethoxypyridazin-4-yl)boronic acid; 3-bromo-N-[2-(3-fluorophenyl)-ethyl]-5-trifluoromethyl-benzenesulfonamide; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 20 ℃; for 0.5h;

In 1,4-dioxane; water; at 80 ℃; for 16h; Alkaline conditions;

DOI:10.1016/j.ejmech.2018.04.018

upstream raw materials:

3,6-dimethoxypyridazine

Downstream raw materials:

N-[4-(3,6-dimethoxy-pyridazin-4-yl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

Refernces

• 1、 Clapham, Kate M.,Batsanov, Andrei S.,Greenwood, Ryan D. R.,Bryce, Martin R.,Smith, Amy E.,Tarbit, Brian. "Functionalized heteroarylpyridazines and pyridazin-3(2H)-one derivatives via palladium-catalyzed cross-coupling methodology". . p. 2176 - 2181. Retrieved 2008/09/19.