3-(2-Methylphenyl)-4-pyridinecarboxylicacid

Base Information

• Chemical Name: 3-(2-Methylphenyl)-4-pyridinecarboxylicacid
• CAS No.: 290300-98-0
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol file: 290300-98-0.mol

Synonyms:3-(2-methylphenyl)pyridine-4-carboxylic acid

Chemical Property of 3-(2-Methylphenyl)-4-pyridinecarboxylicacid

Chemical Property:

• Vapor Pressure: 1.19E-07mmHg at 25°C
• Boiling Point: 415.6°C at 760 mmHg
• Flash Point: 205.2°C
• PSA: 50.19000
• Density: 1.206g/cm³
• LogP: 2.75520

Purity/Quality:

3-(2-METHYLPHENYL)-4-PYRIDINECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Methylphenyl)-4-pyridinecarboxylicacid

There total 2 articles about 3-(2-Methylphenyl)-4-pyridinecarboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-4-pyridinecarboxylic acid (57842-10-1) + 2-Methylphenylboronic acid (16419-60-6) → 3-(o-tolyl)isonicotinic acid (290300-98-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 1,2-dimethoxyethane; water;

Reference yield:

2-Methylphenylboronic acid (16419-60-6) → 3-(o-tolyl)isonicotinic acid (290300-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium carbonate; In tetrahydrofuran; water; toluene;

Reference yield: 55.5%

3-(o-tolyl)isonicotinic acid (290300-98-0) + (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride (1448440-51-4) → (S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)-3-(o-tolyl)isonicotinamide

Guidance literature:

3-(o-tolyl)isonicotinic acid; (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

3-iodo-4-pyridinecarboxylic acid

2-Methylphenylboronic acid