3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Base Information

Chemical Name:3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
CAS No.:947249-19-6
Molecular Formula:C12H19BN2O3
Molecular Weight:250.105
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40694407
Wikidata:Q82623488
Mol file:947249-19-6.mol

Synonyms:947249-19-6;3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine;6-Amino-5-methoxypyridine-3-boronic acid pinacol ester;2-Pyridinamine, 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;SCHEMBL67014;DTXSID40694407;OXNSEGHJPTXNPF-UHFFFAOYSA-N;XMB24919;MFCD11977248;AKOS015950123;PS-12957;CS-0175562;A905259;2-amino-3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

Suppliers and Price of 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 95%
5g
$ 1988.00

Chemcia Scientific
3-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine 95%
2.5 G
$ 695.00

Alfa Aesar
6-Amino-5-methoxypyridine-3-boronic acid pinacol ester, 96%
1g
$ 233.00

Alfa Aesar
6-Amino-5-methoxypyridine-3-boronic acid pinacol ester, 96%
250mg
$ 78.60

AccelPharmtech
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Pyridinamine 97.00%
25G
$ 6710.00

AccelPharmtech
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Pyridinamine 97.00%
5G
$ 3590.00

AccelPharmtech
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Pyridinamine 97.00%
1G
$ 2100.00

Total 8 raw suppliers

Chemical Property of 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

Chemical Property:

Melting Point:98-103℃
PSA：66.60000
LogP:1.55280
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:250.1488726
Heavy Atom Count:18
Complexity:296

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(N=C2)N)OC
Uses 6-Amino-5-Methoxypyridine-3-Boronic Acid Pinacol Ester is used in the preparation and studies of dual leucine zipper kinase inhibitors used in the treatment of Alzheimer''s diseases.

Technology Process of 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

There total 4 articles about 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 42409-58-5
5-bromo-3-methoxy-pyridin-2-amine

: 73183-34-3
bis(pinacol)diborane

: 947249-19-6
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; tricyclohexylphosphine; In 1,4-dioxane; at 110 ℃; for 6h; Inert atmosphere;

Reference yield:

: 20265-37-6
3-methoxy-2-nitropyridine

: 947249-19-6
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 3 h

2.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

2.2: pH 8 / Cooling with ice

3.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; potassium acetate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; methanol; water; ethyl acetate;

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 947249-19-6
3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridine-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; sulfuric acid; acetic acid / water / 2 h / 3 - 5 °C

1.2: pH 8 / Cooling with ice

2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane / 6 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; bromine; potassium acetate; acetic acid; tricyclohexylphosphine; In 1,4-dioxane; water;