5-(4-NITRO-PYRAZOL-1-YLMETHYL)-FURAN-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-(4-NITRO-PYRAZOL-1-YLMETHYL)-FURAN-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 402614-78-2
• Molecular Formula: C₁₀H₉N₃O₅
• Molecular Weight: 251.199
• Hs Code.: 2934999090
• Mol file: 402614-78-2.mol

Synonyms:5-(4-NITRO-PYRAZOL-1-YLMETHYL)-FURAN-2-CARBOXYLIC ACID METHYL ESTER;AKOS B001099;METHYL 5-[(4-NITRO-1H-PYRAZOL-1-YL)METHYL]-2-FUROATE;ART-CHEM-BB B001099;TIMTEC-BB SBB009195;5-[(4-nitro-1-pyrazolyl)methyl]-2-furancarboxylic acid methyl ester;BAS 08302046;methyl 5-[(4-nitropyrazol-1-yl)methyl]furan-2-carboxylate

Chemical Property of 5-(4-NITRO-PYRAZOL-1-YLMETHYL)-FURAN-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 103.08000
• LogP: 1.74240

Purity/Quality:

99% ，98% ^*data from raw suppliers

Methyl 5-[(4-nitro-1H-pyrazol-1-yl)methyl]-2-furoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-NITRO-PYRAZOL-1-YLMETHYL)-FURAN-2-CARBOXYLIC ACID METHYL ESTER

There total 1 articles about 5-(4-NITRO-PYRAZOL-1-YLMETHYL)-FURAN-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-1H-pyrazole (2075-46-9) + methyl 5-(chloromethyl)-2-furoate (2144-37-8) → 5-(4-nitro-pyrazol-1-ylmethyl)-furan-2-carboxylic acid methyl ester (402614-78-2)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetone; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

5-(4-nitro-pyrazol-1-ylmethyl)-furan-2-carboxylic acid methyl ester (402614-78-2) → C18H18ClN3O4

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

4: manganese(IV) oxide / acetonitrile / 20 °C / Inert atmosphere

5: tetrahydrofuran / 2.25 h / -78 - 20 °C / Inert atmosphere

With manganese(IV) oxide; sodium tetrahydroborate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

5-(4-nitro-pyrazol-1-ylmethyl)-furan-2-carboxylic acid methyl ester (402614-78-2) → 5-[4-(2-chloro-benzyloxycarbonylamino)-pyrazol-1-ylmethyl]-furan-2-carboxylic acid methyl ester (1022062-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

4-nitro-1H-pyrazole

methyl 5-(chloromethyl)-2-furoate

Downstream raw materials:

[1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester

[1-(5-formyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester

5-[4-(2-chloro-benzyloxycarbonylamino)-pyrazol-1-ylmethyl]-furan-2-carboxylic acid methyl ester

[1-(5-hydroxymethyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester