2144-37-8Relevant articles and documents
Scalable synthesis of hydroxymethyl alkylfuranoates as stable 2,5-furandicarboxylic acid precursors
Jurys, Arminas,Pedersen, Christian Marcus,Pedersen, Martin J?ger
, p. 2399 - 2402 (2020)
Hydroxymethyl furanoic acid and its derivatives have been synthesized in high yields and purity from gluconolactone. The reaction sequence allows the recovery of reagents and the use of bio-friendly chemicals and solvents, and can easily be scaled up. The reaction product on a >100 gram scale can be purified by a single purification method, such as distillation or precipitation. The overall yield is above 50%.
SYNTHESIS OF PRECURSORS OF 2,5-FURANDICARBOXYLIC ACID
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Page/Page column 25; 26, (2019/10/01)
The present invention relates to a method for the manufacture of stable FDCA precursors from saccharide derived starting materials. More specific the invention relates to the synthesis of FDCA precursors such as alkyl 5-(hydroxymethyl)furan-2-carboxylates or 5-(hydroxymethyl)furan-2-carboxylic acid in an expedient, practical and environmental benign manner from e.g. D-glucono-δ-lactone. These bio-based monomer building blocks hold great potential in the manufacture of polymer materials.
Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents
Su, Hong,Nebbioso, Angela,Carafa, Vincenzo,Chen, Yadong,Yang, Bo,Altucci, Lucia,You, Qidong
, p. 7992 - 8002 (2008/12/23)
A series of hydroxamic acids with conjugated structure was designed and synthesized to explore the possible HDAC subtype selectivity by testing these compounds against recombinant human HDAC1 and HDAC4. The most selective compound resulted 5a, with a SI of 11.9. The enzymatic inhibitory activity of these conjugated compounds was relatively weak; however, some of these compounds showed significant effect in inducing apoptosis. Moreover, the anti-proliferative activity in cancer cells resulted quite promising, especially in the HCT119 cell line.
