Glutamine hydroxamate

Base Information

• Chemical Name: Glutamine hydroxamate
• CAS No.: 1955-67-5
• Molecular Formula: C5H10 N2 O4
• Molecular Weight: 162.145
• Hs Code.: 2928000090
• Nikkaji Number: J441.114E
• Wikidata: Q27093441
• Metabolomics Workbench ID: 147030
• ChEMBL ID: CHEMBL63893
• Mol file: 1955-67-5.mol

Synonyms:gamma-glutamyl hydroxamate;GluNHOH;glutamate-gamma-hydroxamate;glutamate-gamma-hydroxamic acid;glutamic acid gamma-monohydroxamate;glutamyl-gamma-hydroxamate

Chemical Property of Glutamine hydroxamate

Chemical Property:

• Vapor Pressure: 1.46E-14mmHg at 25°C
• Melting Point: 154 °C
• Boiling Point: 553.6°Cat760mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 288.6°C
• PSA: 116.14000
• Density: 1.432g/cm³
• LogP: 0.22450
• Storage Temp.: −20°C
• XLogP3: -4.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 162.06405680
• Heavy Atom Count: 11
• Complexity: 159

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Glutamic acid γ-monohydroxamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CC(=O)NO)C(C(=O)O)N
• Isomeric SMILES: C(CC(=O)NO)[C@@H](C(=O)O)N
• Uses: L-Glutamic acid γ-monohydroxamate has been used as a standard to calculate transglutaminase (TGase) activity.

Technology Process of Glutamine hydroxamate

There total 7 articles about Glutamine hydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-γ-L-glutamyl-4-aminobutyric acid (3183-72-0) → L-Glutamic acid gamma monohydroxamate (1955-67-5) + 4-amino-n-butyric acid (56-12-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium maleate; magnesium chloride; In water; at 37 ℃; for 0.333333h; β-glutamyl transpeptidase (γ-GT), pH 8.0; relative activities of the various γ-glutamyl derivatives compared to S-methylglutathione;

DOI:10.1021/jm00351a003

Reference yield:

monosodium L-glutamate (142-47-2) → L-Glutamic acid gamma monohydroxamate (1955-67-5)

Guidance literature:

With 1H-imidazole; hydroxylamine; magnesium chloride; Methylovorus mays No_. 9 theanine-forming enzyme; In water; at 30 ℃; pH=7.75; Enzyme kinetics;

DOI:10.1271/bbb.60590

Reference yield:

L-γ-glutamyl-L-glutamine (10148-81-9) → L-Glutamic acid gamma monohydroxamate (1955-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: recombinant Pseudomonas nitroreducens IFO12694 γ-glutamyltranspeptidase / 0.03 h / 30 °C / pH 10.5 / aq. buffer; Enzymatic reaction

2: 1H-imidazole; recombinant Pseudomonas nitroreducens IFO12694 γ-glutamyltranspeptidase; hydroxylamine / water / 0.33 h / 30 °C / pH 7.5 / Enzymatic reaction

With 1H-imidazole; recombinant Pseudomonas nitroreducens IFO12694 γ-glutamyltranspeptidase; hydroxylamine; In water;

DOI:10.1271/bbb.100199

upstream raw materials:

(S)-2-Amino-pentanedioic acid 5-ethyl ester

N-γ-L-glutamyl-4-aminobutyric acid

L-glutamine

GLUTATHIONE

Downstream raw materials:

L-glutamic acid

amino phosphoric acid

L-Pyroglutamic acid

Refernces

• 1、 Yamamoto, Sachiko,Wakayama, Mamoru,Tachiki, Takashi. "Characterization of theanine-forming enzyme from Methylovorus mays No. 9 in respect to utilization of theanine production". . p. 545 - 552. Retrieved 2008/03/27.
• 2、 Magnan, Sanne D. J.,Shirota, Frances N.,Nagasawa, Herbert T.. "Drug Latentiation by γ-Glutamyl Transpeptidase". . p. 1018 - 1021. Retrieved 2007/10/02.