pilaralisib

Base Information

Chemical Name:pilaralisib
CAS No.:934526-89-3
Molecular Formula:C25H25ClN6O4S
Molecular Weight:541.0218
Hs Code.:
Mol file:934526-89-3.mol

Synonyms:pilaralisib;Pilaralisib (XL-147);2-Amino-N-[3-[N-[3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide;2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide;XL147(pilaralisib);XL-147,Pilaralisib, SAR245408

Suppliers and Price of pilaralisib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Pilaralisib
10mg
$ 120.00

Medical Isotopes, Inc.
Pilaralisib
5 mg
$ 405.00

DC Chemicals
Pilaralisib(XL-147;SAR245408) >98%
100 mg
$ 450.00

Crysdot
XL-147 98+%
50mg
$ 385.00

ChemScene
Pilaralisib 99.57%
10mg
$ 132.00

ChemScene
Pilaralisib 99.57%
50mg
$ 336.00

ChemScene
Pilaralisib 99.57%
5mg
$ 78.00

Chemenu
2-Amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide 98%
50mg
$ 252.00

Cayman Chemical
Pilaralisib ≥98%
25mg
$ 317.00

Cayman Chemical
Pilaralisib ≥98%
10mg
$ 135.00

Total 25 raw suppliers

Chemical Property of pilaralisib

Chemical Property:

Vapor Pressure:3.22E-16mmHg at 25°C
Boiling Point:638.9°C at 760 mmHg
PKA:6.33±0.30(Predicted)
Flash Point:340.2°C
PSA：166.66000
Density:1.538g/cm³
LogP:5.78640
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Pilaralisib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Pilaralisib is a pan-PI3K inhibitor used in the treatment of patients with chronic lymphocytic leukemia or relapsed or refractory lymphoma.

Technology Process of pilaralisib

There total 5 articles about pilaralisib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-amino-N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide hydrochloride

: 59660-95-6
dimethylaminoacetyl chloride hydrochloride

: 934526-89-3
N-(3-{[(2Z)-3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2(1H)-ylidene]sulfamoyl}phenyl)-2-methylalaninamide

Guidance literature:: 3-amino-N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide hydrochloride; dimethylaminoacetyl chloride hydrochloride; In N,N-dimethyl-formamide; at 5 ℃; Large scale;

With dipotassium hydrogenphosphate; In ethanol; water; N,N-dimethyl-formamide; at 10 ℃; for 2h; Large scale;

Reference yield:

: 1433222-74-2
3-amino-N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide hydrochloride

: 59660-95-6
dimethylaminoacetyl chloride hydrochloride

: 934526-89-3
N-(3-{[(2Z)-3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2(1H)-ylidene]sulfamoyl}phenyl)-2-methylalaninamide

Guidance literature:: In N,N-dimethyl-formamide; at 5 ℃; Large scale;

Reference yield:

: 731815-55-7
(N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide)

: 934526-89-3
N-(3-{[(2Z)-3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2(1H)-ylidene]sulfamoyl}phenyl)-2-methylalaninamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / Reflux; Large scale

2.1: platinum sulfide on carbon / tetrahydrofuran; water; ethanol / Reflux; Large scale

2.2: Reflux; Large scale

2.3: 20 °C / Large scale

3.1: N,N-dimethyl-formamide / 5 °C / Large scale

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;