4-(boc-aminomethyl)pyridine-2-carboxylic acid

Base Information

• Chemical Name: 4-(boc-aminomethyl)pyridine-2-carboxylic acid
• CAS No.: 260970-57-8
• Molecular Formula: C12H16N2O4
• Molecular Weight: 252.27
• Hs Code.: 2933399090
• Mol file: 260970-57-8.mol

Synonyms:4-[(tert-Butoxycarbonylamino)methyl]pyridine-2-carboxylic Acid [Reagent for application of the exciton chirality method]

Chemical Property of 4-(boc-aminomethyl)pyridine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 465.223°C at 760 mmHg
• PKA: 1.02±0.50(Predicted)
• Flash Point: 235.159°C
• PSA: 88.52000
• Density: 1.222g/cm³
• LogP: 2.19540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: slightly sol. in Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-[(tert-Butoxycarbonylamino)methyl]pyridine-2-carboxylic Acid [Reagent for application of the exciton chirality method] >96.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(boc-aminomethyl)pyridine-2-carboxylic acid

There total 5 articles about 4-(boc-aminomethyl)pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Cyano-4-[(tert-butoxycarbonylamino)methyl]pyridine (214472-06-7) → 4-[(tert-butoxycarbonylamino)methyl]pyridine-2-carboxylic acid (260970-57-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1002/(SICI)1521-3765(20000117)6:2<216::AID-CHEM216>3.0.CO;2-1

Reference yield:

4-(aminomethyl)pyridine (3731-53-1) → 4-[(tert-butoxycarbonylamino)methyl]pyridine-2-carboxylic acid (260970-57-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / Et₃N / tetrahydrofuran / 20 °C

2: 82 percent / m-CPBA / CH₂Cl₂ / 12 h / 20 °C

3: 53 percent / dimethylcarbamyl chloride / CH₂Cl₂ / 48 h / 20 °C

4: 100 percent / aq. NaOH / ethanol / 24 h / Heating

With sodium hydroxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; ethanol; dichloromethane; 1: Acylation / 2: Oxidation / 3: Substitution / 4: Hydrolysis;

DOI:10.1002/(SICI)1521-3765(20000117)6:2<216::AID-CHEM216>3.0.CO;2-1

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-[(tert-butoxycarbonylamino)methyl]pyridine-2-carboxylic acid (260970-57-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / Et₃N / tetrahydrofuran / 20 °C

2: 82 percent / m-CPBA / CH₂Cl₂ / 12 h / 20 °C

3: 53 percent / dimethylcarbamyl chloride / CH₂Cl₂ / 48 h / 20 °C

4: 100 percent / aq. NaOH / ethanol / 24 h / Heating

With sodium hydroxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; ethanol; dichloromethane; 1: Acylation / 2: Oxidation / 3: Substitution / 4: Hydrolysis;

DOI:10.1002/(SICI)1521-3765(20000117)6:2<216::AID-CHEM216>3.0.CO;2-1

upstream raw materials:

2-Cyano-4-[(tert-butoxycarbonylamino)methyl]pyridine

4-(aminomethyl)pyridine

di-tert-butyl dicarbonate

(pyridin-4-ylmethyl)carbamic acid tert-butyl ester

Downstream raw materials:

N-((2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)pivalamide

(4-(aminomethyl)pyridin-2-yl)(4-(4-chlorophenoxy)piperidin-1-yl)methanone

tert-butyl ((2-(4-(4-chlorophenoxy)piperidine-1-carbonyl)pyridin-4-yl)methyl)carbamate

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