4-[(tert-butoxycarbonylamino)methyl]-2-cyanopyridine

Base Information

Chemical Name:4-[(tert-butoxycarbonylamino)methyl]-2-cyanopyridine
CAS No.:214472-06-7
Molecular Formula:C₁₂H₁₅N₃O₂
Molecular Weight:233.27
Hs Code.:29333990
Mol file:214472-06-7.mol

Synonyms:Pyridine-4-N-Boc-aminomethyl-2-nitrile;4-[(tert-Butoxycarbonylamino)methyl]-2-cyanopyridine;(2-cyano-pyridin-4-ylmethyl)-carbamic acid tert-butyl ester;4-(Boc-aminomethyl)-2-cyanopyridine;2-Cyano-4-[(tert-butoxycarbonylamino)methyl]pyridine;

Suppliers and Price of 4-[(tert-butoxycarbonylamino)methyl]-2-cyanopyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
4-[(tert-Butoxycarbonylamino)methyl]-2-cyanopyridine >98.0%(HPLC)(N)
1g
$ 867.00

Frontier Specialty Chemicals
4-(Boc-aminomethyl)-2-cyanopyridine 97%
1g
$ 729.00

Crysdot
4-[(tert-Butoxycarbonylamino)methyl]-2-cyanopyridine 95+%
1g
$ 549.00

Chemenu
4-[(tert-Butoxycarbonylamino)methyl]-2-cyanopyridine 95%
1g
$ 518.00

American Custom Chemicals Corporation
4-(BOC-AMINOMETHYL)-2-CYANOPYRIDINE 95.00%
5MG
$ 501.14

Alichem
4-[(tert-Butoxycarbonylamino)methyl]-2-cyanopyridine
1g
$ 548.46

AK Scientific
Pyridine-4-N-Boc-aminomethyl-2-nitrile
1g
$ 1267.00

Total 12 raw suppliers

Chemical Property of 4-[(tert-butoxycarbonylamino)methyl]-2-cyanopyridine

Chemical Property:

Vapor Pressure:3.57E-07mmHg at 25°C
Refractive Index:1.527
Boiling Point:417.3ºC at 760 mmHg
Flash Point:206.2ºC
PSA：78.50000
Density:1.15g/cm3
LogP:2.18238

Purity/Quality:

97% ^*data from raw suppliers

4-[(tert-Butoxycarbonylamino)methyl]-2-cyanopyridine >98.0%(HPLC)(N) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[(tert-butoxycarbonylamino)methyl]-2-cyanopyridine

There total 5 articles about 4-[(tert-butoxycarbonylamino)methyl]-2-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 7677-24-9
trimethylsilyl cyanide

: 111080-66-1
4-[(tert-Butoxycarbonylamino)methyl]pyridine oxide

: 214472-06-7
2-Cyano-4-[(tert-butoxycarbonylamino)methyl]pyridine

Guidance literature:: With N,N-Dimethylcarbamoyl chloride; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1002/(SICI)1521-3765(20000117)6:2<216::AID-CHEM216>3.0.CO;2-1

Reference yield:

: 111080-65-0
(pyridin-4-ylmethyl)carbamic acid tert-butyl ester

: 214472-06-7
2-Cyano-4-[(tert-butoxycarbonylamino)methyl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / mCPBA / CH₂Cl₂ / 12 h / 20 °C

2: 53 percent / (CH₃)2NCOCl / CH₂Cl₂ / 48 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In dichloromethane;
DOI:10.1021/ol026527t

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 214472-06-7
2-Cyano-4-[(tert-butoxycarbonylamino)methyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / TEA / tetrahydrofuran / 20 °C

2: 80 percent / mCPBA / CH₂Cl₂ / 12 h / 20 °C

3: 53 percent / (CH₃)2NCOCl / CH₂Cl₂ / 48 h / 20 °C

With TEA; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol026527t