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220199-85-9

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220199-85-9 Usage

General Description

1-N-BOC-MORPHOLINE is a chemical compound that belongs to the class of morpholine derivatives. It is a white to pale yellow solid that is sparingly soluble in water and polar organic solvents. 1-N-BOC-MORPHOLINE, also known as N-tert-Butoxycarbonyl-morpholine, is commonly used as a reagent in organic synthesis and pharmaceutical research. It serves as a versatile intermediate for the synthesis of various biologically active compounds and drugs. The BOC (tert-butoxycarbonyl) group provides protection for the morpholine nitrogen atom, allowing for selective functionalization in chemical reactions. 1-N-BOC-MORPHOLINE is also used as a building block in the preparation of peptide and polyester materials. It is important to handle this compound with care and follow proper safety precautions, as it may pose health hazards if not handled properly.

Check Digit Verification of cas no

The CAS Registry Mumber 220199-85-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,1,9 and 9 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 220199-85:
(8*2)+(7*2)+(6*0)+(5*1)+(4*9)+(3*9)+(2*8)+(1*5)=119
119 % 10 = 9
So 220199-85-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H17NO3/c1-9(2,3)13-8(11)10-4-6-12-7-5-10/h4-7H2,1-3H3

220199-85-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl morpholine-4-carboxylate

1.2 Other means of identification

Product number -
Other names morpholine-4-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:220199-85-9 SDS

220199-85-9Relevant articles and documents

Sustainable Route Toward N-Boc Amines: AuCl3/CuI-Catalyzed N-tert-butyloxycarbonylation of Amines at Room Temperature

Cao, Yanwei,Huang, Yang,He, Lin

, (2021/12/22)

N-tert-butoxycarbonyl (N-Boc) amines are useful intermediates in synthetic/medicinal chemistry. Traditionally, they are prepared via an indirect phosgene route with poor atom economy. Herein, a step- and atom-economic synthesis of N-Boc amines from amines, t-butanol, and CO was reported at room temperature. Notably, this N-tert-butyloxycarbonylation procedure utilized ready-made substrates, commercially available AuCl3/CuI as catalysts, and O2 from air as the sole oxidant. This catalytic system provided unique selectivity for N-Boc amines in good yields. More significantly, gram-scale preparation of medicinally important N-Boc amine intermediates was successfully implement, which demonstrated a potential application prospect in industrial syntheses. Furthermore, this approach also showed good compatibility with tertiary and other useful alcohols. Investigations of the mechanisms revealed that gold catalyzed the reaction and copper acted as electron transfer mediator in the catalytic cycle.

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

Pise, Ashok S.,Ingale, Ajit P.,Dalvi, Navnath R.

supporting information, p. 3768 - 3780 (2021/10/26)

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Ingale, Ajit P.,Shinde, Sandeep V.,Thorat, Nitin M.

supporting information, p. 2528 - 2543 (2021/07/02)

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

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