2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine

Base Information

• Chemical Name: 2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine
• CAS No.: 883908-27-8
• Molecular Formula: C17H20BrN3
• Molecular Weight: 346.27
• Hs Code.: 2933599090
• Mol file: 883908-27-8.mol

Synonyms:2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine

Chemical Property of 2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine

Chemical Property:

• PSA: 32.50000
• LogP: 3.93760

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine

There total 4 articles about 2-(4-Benzyl-1-piperazinyl)-5-bromophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyl-4-(4-bromo-2-nitro-phenyl)-piperazine (883522-59-6) → 1-benzyl-4-(2-amino-4-bromo-phenyl)-piperazine (883908-27-8)

Guidance literature:

With sodium dithionate; sodium carbonate; In methanol; water; at 70 ℃;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

1,4-dibromo-2-nitrobenzene (3460-18-2) → 1-benzyl-4-(2-amino-4-bromo-phenyl)-piperazine (883908-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / propan-2-ol / 24 h / 70 °C

2: 86 percent / Zn; aq. KH₂PO₄ / tetrahydrofuran / 24 h / 80 °C

With potassium dihydrogenphosphate; zinc; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/jm0602864

Reference yield:

1-phenylmethylpiperazine (2759-28-6) → 1-benzyl-4-(2-amino-4-bromo-phenyl)-piperazine (883908-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / propan-2-ol / 24 h / 70 °C

2: 86 percent / Zn; aq. KH₂PO₄ / tetrahydrofuran / 24 h / 80 °C

With potassium dihydrogenphosphate; zinc; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1021/jm0602864

upstream raw materials:

1-benzyl-4-(4-bromo-2-nitro-phenyl)-piperazine

1-phenylmethylpiperazine

1,4-dibromo-2-nitrobenzene

Downstream raw materials:

2-oxo-2H-chromene-3-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

N-(2-(4-benzylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

N-(2-(4-Benzylpiperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide

N-(2-(4-benzylpiperazin-1-yl)-5-bromophenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

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