naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

Base Information

Chemical Name:naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide
CAS No.:883908-06-3
Molecular Formula:C₂₈H₂₆BrN₃O
Molecular Weight:500.438
Hs Code.:

Synonyms:naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

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Chemical Property of naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

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Technology Process of naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

There total 4 articles about naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 883908-27-8
1-benzyl-4-(2-amino-4-bromo-phenyl)-piperazine

: 879-18-5
naphthalene-1-carbonic acid chloride

: 883908-06-3
naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm0602864

Reference yield:

: 883522-59-6
1-benzyl-4-(4-bromo-2-nitro-phenyl)-piperazine

: 883908-06-3
naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Zn; aq. KH₂PO₄ / tetrahydrofuran / 24 h / 80 °C

2: 75 percent / DIEA / CH₂Cl₂ / 4 h / 20 °C

With potassium dihydrogenphosphate; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0602864

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 883908-06-3
naphthalene-1-carboxylic acid [2-(4-benzyl-piperazin-1-yl)-5-bromo-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / propan-2-ol / 24 h / 70 °C

2: 86 percent / Zn; aq. KH₂PO₄ / tetrahydrofuran / 24 h / 80 °C

3: 75 percent / DIEA / CH₂Cl₂ / 4 h / 20 °C

With potassium dihydrogenphosphate; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm0602864