α-Phenyl-4-methylbenzeneethanol

Base Information

• Chemical Name: α-Phenyl-4-methylbenzeneethanol
• CAS No.: 20498-68-4
• Molecular Formula: C15H16O
• Molecular Weight: 212.291
• Hs Code.: 2902909090
• Mol file: 20498-68-4.mol

Synonyms:1-Phenyl-2-(p-tolyl)ethanol;1-Phenyl-2-p-tolylethanol;α-Phenyl-4-methylbenzeneethanol

Chemical Property of α-Phenyl-4-methylbenzeneethanol

Chemical Property:

• PSA: 20.23000
• LogP: 3.27110

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Phenyl-4-methylbenzeneethanol

There total 32 articles about α-Phenyl-4-methylbenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

phenylacetaldehyde (122-78-1) + phenylboronic acid (98-80-6) → 1-phenyl-2-(4-methylphenyl)ethanol (20498-68-4)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; water; In toluene; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201101191

Reference yield: 91.0%

butyl(isopropoxy)(methyl)(4-methylbenzyl)silane (1403470-88-1) + benzaldehyde (100-52-7) → 1-phenyl-2-(4-methylphenyl)ethanol (20498-68-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/ja307956w

Reference yield: 89.0%

2-(4-methylphenyl)oxirane (13107-39-6) + phenylboronic acid (98-80-6) → 1-phenyl-2-(4-methylphenyl)ethanol (20498-68-4)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; water; In toluene; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201101191

upstream raw materials:

styrene oxide

p-tolyllithium

1-phenyl-2-p-tolylethanone

4-methylbibenzyl

Downstream raw materials:

1-Chloro-1-phenyl-2-p-tolylethan

(R)-1-acetoxy-1-phenyl-2-(p-tolyl)ethane

benzaldehyde

(S)-1-butyryloxy-1-phenyl-2-(4-methylphenyl)ethane