BENZENE, 2-CHLORO-1-FLUORO-3-METHOXY-

Base Information

• Chemical Name: BENZENE, 2-CHLORO-1-FLUORO-3-METHOXY-
• CAS No.: 446-60-6
• Molecular Formula: C7H6ClFO
• Molecular Weight: 160.575
• Hs Code.: 2909309090
• Mol file: 446-60-6.mol

Synonyms:BENZENE, 2-CHLORO-1-FLUORO-3-METHOXY-;2-Chloro-3-fluoroanisole;2-chloro-1-fluoro-3-Methoxybenzene

Chemical Property of BENZENE, 2-CHLORO-1-FLUORO-3-METHOXY-

Chemical Property:

• Boiling Point: 174.3±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.239±0.06 g/cm3(Predicted)
• LogP: 2.48770

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-1-fluoro-3-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZENE, 2-CHLORO-1-FLUORO-3-METHOXY-

There total 3 articles about BENZENE, 2-CHLORO-1-FLUORO-3-METHOXY- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-3-fluorophenol (863870-86-4) + methyl iodide (74-88-4) → 2-chloro-1-fluoro-3-methoxybenzene (446-60-6)

Guidance literature:

With potassium carbonate; for 16h; Reflux;

Reference yield:

1-fluoro-3-methoxy-2-nitrobenzene (641-49-6) → 2-chloro-1-fluoro-3-methoxybenzene (446-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; aqueous acetic acid

2: Diazotization

With iron; acetic acid;

Reference yield:

2-fluoro-6-methoxyphenylamine (446-61-7) → 2-chloro-1-fluoro-3-methoxybenzene (446-60-6)

Guidance literature:

Diazotization;

upstream raw materials:

2-fluoro-6-methoxyphenylamine

1-fluoro-3-methoxy-2-nitrobenzene

2-chloro-3-fluorophenol

methyl iodide

Downstream raw materials:

1-bromo-3-chloro-2-fluoro-4-methoxybenzene

methyl 7-chloro-6-methoxybenzo[b]thiophene-2-carboxylate

Refernces

• 1、 -. "ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES". Paragraph 0156-0158. . Retrieved 2019/12/31.