Schisandrol A

Base Information

Chemical Name:Schisandrol A
CAS No.:7432-28-2
Molecular Formula:C₂₄H₃₂O₇
Molecular Weight:432.514
Hs Code.:29093090
European Community (EC) Number:694-563-5
Nikkaji Number:J674.795G
Wikidata:Q104397519
ChEMBL ID:CHEMBL1669433
Mol file:7432-28-2.mol

Synonyms:schisandrol A

Suppliers and Price of Schisandrol A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Schizandrol A
20mg
$ 297.00

TRC
Schizandrol
50mg
$ 240.00

Sigma-Aldrich
Schizandrin ≥98% (HPLC)
10mg
$ 68.80

Sigma-Aldrich
Schizandrin ≥98% (HPLC)
50mg
$ 279.00

Sigma-Aldrich
Schizandrin European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Schizandrin EuropePharmacopoeia (EP) Reference Standard
y0001818
$ 190.00

Sigma-Aldrich
Schisandrin United States Pharmacopeia (USP) Reference Standard
15mg
$ 320.00

Medical Isotopes, Inc.
Schizandrol
50 mg
$ 695.00

JR MediChem
Schisandrol?A 98%
50mg
$ 158.00

DC Chemicals
Schisandrin >98%
20 mg
$ 280.00

Total 144 raw suppliers

Chemical Property of Schisandrol A

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:3.87E-14mmHg at 25°C
Melting Point:128-129oC
Refractive Index:1.535
Boiling Point:576.7 °C at 760 mmHg
PKA:14.58±0.40(Predicted)
Flash Point:302.6 °C
PSA：75.61000
Density:1.135 g/cm³
LogP:3.89090
Storage Temp.:room temp
Solubility.:DMSO: ≥13mg/mL
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:432.21480336
Heavy Atom Count:31
Complexity:574

Purity/Quality:

9%, ^*data from raw suppliers

Schizandrol A ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,N
Hazard Codes:Xn,N
Statements: 22-50/53
Safety Statements: 60-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1(C)O)OC)OC)OC)OC)OC)OC
Isomeric SMILES:C[C@H]1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3C[C@@]1(C)O)OC)OC)OC)OC)OC)OC
Description Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.
Uses Schizandrin may be used in oxidative stress-related cell signaling studies.

Technology Process of Schisandrol A

There total 73 articles about Schisandrol A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%