4-Hydroxymidazolam b-D-Glucuronide

Base Information

• Chemical Name: 4-Hydroxymidazolam b-D-Glucuronide
• CAS No.: 81256-82-8
• Molecular Formula: C₂₄H₂₁ClFN₃O₇
• Molecular Weight: 517.898
• Mol file: 81256-82-8.mol

Synonyms:4-Hydroxymidazolam b-D-Glucuronide;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl b-D-Glucopyranosiduronic Acid;4-Hydroxymidazolam -D-Glucuronide;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl -D-Glucopyranosiduronic Acid;4-Hydroxy MidazolaM β-D-Glucuronide (Mixture of DiastereoMers)

Chemical Property of 4-Hydroxymidazolam b-D-Glucuronide

Chemical Property:

• Melting Point: >205°C (dec.)
• PSA: 146.63000
• LogP: 1.16720
• Storage Temp.: Controlled Substance, -20?C Freezer, Under Inert Atmosphere

Purity/Quality:

(4-Hydroxymidazolam)-β-D-glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of midazolam The metabolite of Midazolam (M343000).

Technology Process of 4-Hydroxymidazolam b-D-Glucuronide

There total 1 articles about 4-Hydroxymidazolam b-D-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

uridine diphosphoglucuronic acid (2616-64-0,7305-43-3,50722-58-2,106864-00-0,14520-48-0,30329-32-9,3545-73-1,5918-40-1) + 4-hydroxymidazolam (59468-85-8) → 4-Hydroxymidazolam O-glucuronide (81256-82-8)

Guidance literature:

With human liver microsomes; at 37 ℃; for 1h; pH=7.5; Reagent/catalyst; Kinetics; aq. buffer;

DOI:10.1124/dmd.110.035295

upstream raw materials:

uridine diphosphoglucuronic acid

4-hydroxymidazolam