Sulfone, bis((4-chloroacetylamino)phenyl)

Base Information

Chemical Name:Sulfone, bis((4-chloroacetylamino)phenyl)
CAS No.:17328-16-4
Molecular Formula:C16H14Cl2N2O4S
Molecular Weight:401.27
Hs Code.:2924299090
NSC Number:30176
DSSTox Substance ID:DTXSID40169569
Nikkaji Number:J48.748A
Wikidata:Q83039287
ChEMBL ID:CHEMBL1797447
Mol file:17328-16-4.mol

Synonyms:TC-E 5003;17328-16-4;NSC 30176;Sulfone, bis((4-chloroacetylamino)phenyl);N,N'-(Sulfonylbis(4,1-phenylene))bis(2-chloroacetamide);N,N'-[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide);NSC30176;N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide);CHEMBL1797447;2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide;MFCD00028183;BRN 2180613;4',4'''-Sulfonylbis(beta-chloracetanilide);Acetanilide, 4',4'''-sulfonylbis(2-chloro-;4-(2,2-DICHLOROACETAMIDO)PHENYL SULFONE;4',4''-SULFONYLBIS(2-CHLOROACETANILIDE);SCHEMBL10996832;Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis(2-chloro-;DTXSID40169569;TCE5003;TC-E5003;AC2496;BDBM50346713;NSC-30176;AKOS024431411;Acetanilide,4'''-sulfonylbis[2-chloro-;AS-16732;SY233006;HY-107574;CS-0028894;4',4'''-Sulfonylbis(.beta.-chloracetanilide);A16378;A921688;J-010894;Acetamide,N'-(sulfonyldi-4,1-phenylene)bis[2-chloro-;N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);N,N inverted exclamation mark -[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide)

Suppliers and Price of Sulfone, bis((4-chloroacetylamino)phenyl)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TC-E 5003
50mg
$ 296.00

TRC
NSC30176
10mg
$ 60.00

Tocris
TC-E5003 ≥98%(HPLC)
50
$ 75.00

DC Chemicals
TC-E5003
003
$ 1200.00

DC Chemicals
TC-E5003
002
$ 600.00

DC Chemicals
TC-E5003
001
$ 350.00

CSNpharm
TC-E5003
10mg
$ 30.00

CSNpharm
TC-E5003
100mg
$ 115.00

Cayman Chemical
TC-E 5003 ≥98%
500 mg
$ 315.00

Cayman Chemical
TC-E 5003 ≥95%
50mg
$ 56.00

Total 9 raw suppliers

Chemical Property of Sulfone, bis((4-chloroacetylamino)phenyl)

Chemical Property:

Boiling Point:704.2°Cat760mmHg
Flash Point:379.7°C
PSA：100.72000
Density:1.504g/cm³
LogP:4.10080
Storage Temp.:-20°C (des.)
Solubility.:Soluble in DMSO (up to 50 mg/ml).
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:400.0051335
Heavy Atom Count:25
Complexity:519

Purity/Quality:

97% ^*data from raw suppliers

TC-E 5003 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl
Description TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.
Uses NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.

Technology Process of Sulfone, bis((4-chloroacetylamino)phenyl)

There total 3 articles about Sulfone, bis((4-chloroacetylamino)phenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.5%