2 , 5-DIBROMO-4-METHYLTHIAZOLE

Base Information

• Chemical Name: 2 , 5-DIBROMO-4-METHYLTHIAZOLE
• CAS No.: 170172-38-0
• Molecular Formula: C₄H₃Br₂NS
• Molecular Weight: 256.949
• Mol file: 170172-38-0.mol

Synonyms:2 , 5-DIBROMO-4-METHYLTHIAZOLE

Chemical Property of 2 , 5-DIBROMO-4-METHYLTHIAZOLE

Chemical Property:

Purity/Quality:

>98% ^*data from raw suppliers

2,5-Dibromo-4-methylthiazole AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2 , 5-DIBROMO-4-METHYLTHIAZOLE

There total 2 articles about 2 , 5-DIBROMO-4-METHYLTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-4-methylthiazol-2-ylammonium bromide (79247-77-1) → 2,5-dibromo-4-methylthiazole (79247-78-2,170172-38-0)

Guidance literature:

With sulfuric acid; copper(II) sulfate; sodium bromide; sodium nitrite; In water; 1.) 3 deg C, 30 min, 2.) 20 deg C, 30 min;

DOI:10.1039/P19810002335

Reference yield:

4-methylthiazol-2-ylamine (1603-91-4) → 2,5-dibromo-4-methylthiazole (79247-78-2,170172-38-0)

Guidance literature:

With hydrogen bromide; sodium nitrite; anschliessendes Erwaermen mit Brom;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2,5-dibromo-4-methylthiazole (79247-78-2,170172-38-0) + carbon dioxide (124-38-9,18923-20-1) → methyl 5-bromo-4-methylthiazole-2-carboxylate (79247-79-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) hexane, -60 deg C, 1 h, 2.) ether, 3.) ether, 5 min;

DOI:10.1039/P19810002335

upstream raw materials:

4-methylthiazol-2-ylamine

5-bromo-4-methylthiazol-2-ylammonium bromide

Downstream raw materials:

methyl 5-bromo-4-methylthiazole-2-carboxylate

ethyl 5-bromo-4-methylthiazole-2-carboxylate

5-bromo-4-methyl-thiazole-2-carboxylic acid

Refernces

• 1、 Kaye, Perry T.,Meakins, G. Denis,Willbe, Charles,Williams, Peter R.. "An Infrared Study of Rotational Isomerism in Thiazole-2-carboxylates". . p. 2335 - 2339. Retrieved 2007/10/02.