N,2-DiMethyl-benzeneethanaMine

Base Information

• Chemical Name: N,2-DiMethyl-benzeneethanaMine
• CAS No.: 756500-61-5
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.236
• Hs Code.: 2921499090
• Mol file: 756500-61-5.mol

Synonyms:N,2-DiMethyl-benzeneethanaMine;N-[2-(2-Methylphenyl)ethyl]-N-methylamine

Chemical Property of N,2-DiMethyl-benzeneethanaMine

Chemical Property:

• PSA: 12.03000
• LogP: 2.14780

Purity/Quality:

99% ^*data from raw suppliers

N-[2-(2-Methylphenyl)ethyl]-N-methylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,2-DiMethyl-benzeneethanaMine

There total 10 articles about N,2-DiMethyl-benzeneethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Methyl (2-methylphenethyl)carbamate → N-methyl-2-(o-tolyl)ethan-1-amine (756500-61-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1021/acs.jmedchem.0c01441

Reference yield:

2-methylphenethylamine (55755-16-3) → N-methyl-2-(o-tolyl)ethan-1-amine (756500-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.5 h / 0 - 20 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 5 h / Inert atmosphere

3.1: hydrogenchloride / water; ethyl acetate / 3 h

With hydrogenchloride; sodium hydride; In tetrahydrofuran; water; ethyl acetate; mineral oil;

DOI:10.1021/acs.joc.9b01769

Reference yield:

N-methyl-2-(o-tolyl)acetamide (909373-25-7) → N-methyl-2-(o-tolyl)ethan-1-amine (756500-61-5)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/ja401610p

upstream raw materials:

1-(2-bromoethyl)-2-methylbenzene

methylamine

ortho-tolylmagnesium bromide

2-o-tolylethanol

Downstream raw materials:

2-cyano-N-methyl-N-(2-methylphenethyl)acetamide