N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE

Base Information

• Chemical Name: N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE
• CAS No.: 158861-38-2
• Molecular Formula: C29H34N2O4S
• Molecular Weight: 506.666
• Mol file: 158861-38-2.mol

Synonyms:N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE;[(1R)-2-(MethoxyMethylaMino)-2-oxo-1-[[(triphenylMethyl)thio]Methyl]ethyl]carbaMic Acid 1,1-DiMethylethyl Ester

Chemical Property of N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE

Chemical Property:

• PSA: 96.66000
• Density: 1.164g/cm³
• LogP: 5.82920
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-S-tritylcystein-N-methoxy-N-methylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE

There total 4 articles about N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-tert-butyloxycarbonyl-S-trityl-L-cysteine (21947-98-8,87494-13-1) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (R)-N-methyl-N-methoxy-2-tert-butoxycarbonylamino-3-(triphenylmethylthio)propionamide (158861-38-2)

Guidance literature:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -15 ℃; for 0.25h;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/ol051489+

Reference yield: 92.0%

→ (R)-N-methyl-N-methoxy-2-tert-butoxycarbonylamino-3-(triphenylmethylthio)propionamide (158861-38-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine (21947-98-8,87494-13-1) → (R)-N-methyl-N-methoxy-2-tert-butoxycarbonylamino-3-(triphenylmethylthio)propionamide (158861-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylpiperidine / CH₂Cl₂ / 0.08 h / -20 °C

2: N-methylpiperidine / CH₂Cl₂

With N-methylcyclohexylamine; In dichloromethane;

DOI:10.1021/jm00032a004

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

N-tert-butyloxycarbonyl-S-trityl-L-cysteine

Downstream raw materials:

N-[2-(N-tert-butyloxycarbonylamino)-2-(S-tritylthiomethyl)ethyl]glycine methyl ester

[[(6-benzyloxycarbonylamino-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-3-tritylsulfanyl-propyl)-amino]-acetic acid methyl ester

[[(6-benzyloxycarbonylamino-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-3-tritylsulfanyl-propyl)-amino]-acetic acid

C₂₇H₂₉NO₂S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 158861-38-2 N-BOC-S-TRITYLCYSTEIN-N-METHOXY-N-METHYLAMIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send