BAY 1000394

Base Information

Chemical Name:BAY 1000394
CAS No.:1223498-69-8
Molecular Formula:C18H21F3N4O3S
Molecular Weight:430.451
Hs Code.:
Mol file:1223498-69-8.mol

Synonyms:BAY 1000394;Roniciclib;BAY 1000394 (Roniciclib)

Suppliers and Price of BAY 1000394

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BAY1000394
5mg
$ 1525.00

TRC
BAY1000394
2.5mg
$ 815.00

ChemScene
Roniciclib 98.89%
100mg
$ 3500.00

ChemScene
Roniciclib 98.89%
50mg
$ 2000.00

ChemScene
Roniciclib 98.89%
10mg
$ 550.00

ChemScene
Roniciclib 98.89%
5mg
$ 350.00

Total 9 raw suppliers

Chemical Property of BAY 1000394

Chemical Property:

Boiling Point:577.4±60.0 °C(Predicted)
PSA：116.57000
Density:1.50±0.1 g/cm3(Predicted)
LogP:4.99360

Purity/Quality:

97% ^*data from raw suppliers

BAY1000394 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses BAY 1000394 (Roniciclib)l is a type I pan-CDK inhibitor which is used in xenograft cancer models. Anticancer agent.

Technology Process of BAY 1000394

There total 21 articles about BAY 1000394 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1365543-64-1
N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

: 1223498-69-8
(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Guidance literature:: N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt; With palladium 10% on activated carbon; hydrogen; In methanol; for 6h; under 760.051 Torr;

With potassium carbonate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1223498-94-9
(R,S)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-N-(trifluoroacetyl)sulfoximide

: 1223498-67-6
(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

: 1223498-69-8
(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1.5h;

Reference yield:

: 1223498-43-8
(R,S)-S-cyclopropyl-S-(4-nitrophenyl)-N-(trifluoroacetyl)sulfoximide

: 1223498-67-6
(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

: 1223498-69-8
(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 6.25 h / 25 °C / 760.05 Torr

2: hydrogenchloride / 1,4-dioxane; acetonitrile / 5 h / 80 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

4: potassium carbonate / methanol / 1.5 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; acetonitrile;