(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Base Information

Chemical Name:(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide
CAS No.:1223498-67-6
Molecular Formula:C₁₈H₂₁F₃N₄O₃S
Molecular Weight:430.451
Hs Code.:

Synonyms:(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

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Chemical Property of (S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

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Technology Process of (S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

There total 13 articles about (S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1223498-94-9
(R,S)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-N-(trifluoroacetyl)sulfoximide

: 1223498-67-6
(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

: 1223498-69-8
(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 1.5h;

Reference yield:

: 1223498-43-8
(R,S)-S-cyclopropyl-S-(4-nitrophenyl)-N-(trifluoroacetyl)sulfoximide

: 1223498-67-6
(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

: 1223498-69-8
(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 6.25 h / 25 °C / 760.05 Torr

2: hydrogenchloride / 1,4-dioxane; acetonitrile / 5 h / 80 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

4: potassium carbonate / methanol / 1.5 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; acetonitrile;

Reference yield:

: 1223498-44-9
(R,S)-S-(4-aminophenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

: 1223498-67-6
(S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

: 1223498-69-8
(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; acetonitrile / 5 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

3: potassium carbonate / methanol / 1.5 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; acetonitrile;