N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide
CAS No.:1403332-60-4
Molecular Formula:C₂₅H₂₅N₅O₂
Molecular Weight:427.506
Hs Code.:
Mol file:1403332-60-4.mol

Synonyms:N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

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Technology Process of N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

There total 5 articles about N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1403333-73-2
ethyl 1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxylate

: 100-46-9
benzylamine

: 1403332-60-4
N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In tetrahydrofuran; at 130 ℃; for 0.333333h; Inert atmosphere; microwave irradiation;

Reference yield:

: 496863-48-0
1-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone

: 1403332-60-4
N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate / tetrahydrofuran / -7 °C / Inert atmosphere

1.2: 2.5 h / -11 - 20 °C

2.1: sodium acetate; acetic acid / ethanol / 2 h / 80 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

4.1: potassium carbonate; N,N-dimethyl-formamide / 3 h / 70 °C

5.1: bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct / tetrahydrofuran / 0.33 h / 130 °C / Inert atmosphere; microwave irradiation

With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; sodium acetate; potassium carbonate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1403333-53-8
ethyl 4-[2-(methylsulfanyl)pyrimidin-4-yl]-2,4-dioxobutanoate

: 1403332-60-4
N-benzyl-1-tert-butyl-5-(2-phenoxypyrimidin-4-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate; acetic acid / ethanol / 2 h / 80 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

3: potassium carbonate; N,N-dimethyl-formamide / 3 h / 70 °C

4: bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct / tetrahydrofuran / 0.33 h / 130 °C / Inert atmosphere; microwave irradiation

With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; sodium acetate; potassium carbonate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;