methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate

Base Information

Chemical Name:methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate
CAS No.:201294-27-1
Molecular Formula:C11H11NO4
Molecular Weight:221.20934
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20441759
Nikkaji Number:J924.658D
Mol file:201294-27-1.mol

Synonyms:201294-27-1;methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate;Methyl 4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;methyl 4-methyl-3-oxo-1,4-benzoxazine-7-carboxylate;SCHEMBL474743;DTXSID20441759;FEINYHJHLMHJSV-UHFFFAOYSA-N;MFCD11553034;AKOS005072898;HC-0704;J-522376;Methyl4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;3-Oxo-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid methyl ester;4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

Suppliers and Price of methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate >95%
500mg
$ 244.00

Crysdot
Methyl4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 95+%
5g
$ 769.00

Chemenu
Methyl4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 95%
5g
$ 726.00

AK Scientific
Methyl4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate
500mg
$ 379.00

Total 2 raw suppliers

Chemical Property of methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate

Chemical Property:

Melting Point:148-151°
PSA：55.84000
LogP:0.89340
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:221.06880783
Heavy Atom Count:16
Complexity:304

Purity/Quality:

97% ^*data from raw suppliers

Methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C(=O)COC2=C1C=CC(=C2)C(=O)OC

Technology Process of methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate

There total 3 articles about methyl 4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 142166-00-5
methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate

: 201294-27-1
methyl 4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1248/cpb.45.1975

Reference yield: 65.0%

: 214848-62-1
3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid

: 74-88-4
methyl iodide

: 201294-27-1
methyl 4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

: 63435-16-5
3-hydroxy-4-aminobenzoic acid methyl ester

: 201294-27-1
methyl 4-methyl-3-oxo-2H-1,4-benzoxazine-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / aq. NaHCO₃ / ethyl acetate / 0.5 h / Ambient temperature

2: 77 percent / NaH / dimethylformamide / 60 °C

With sodium hydride; sodium hydrogencarbonate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1975