1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine

Base Information

• Chemical Name: 1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine
• CAS No.: 1094359-30-4
• Molecular Formula: C₂₃H₃₈N₂O₃S
• Molecular Weight: 422.632
• Mol file: 1094359-30-4.mol

Synonyms:1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine

Chemical Property of 1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine

There total 1 articles about 1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,6,6-tetramethyl-piperidine-N-oxyl (2564-83-2) + N-tosyl-(2,2-dimethyl)-pent-4-enylamine (95106-72-2) → 1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine (1094359-30-4) + 1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine

Guidance literature:

With oxygen; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; (4R,4'R,5S,5'S)-2,2'-(propane-2,2-diyl)bis(4,5-diphenyl-4,5-dihydrooxazole); In α,α,α-trifluorotoluene; at 120 ℃; for 24h; under 760.051 Torr; optical yield given as %ee;

DOI:10.1021/ja806585m

Reference yield: 66.0%

1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine (1094359-30-4) → (S)-(+)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol (212890-85-2)

Guidance literature:

1-[4,4-dimethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethoxy]-2,2,6,6-tetramethyl-piperidine; With ammonia; lithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

With water; ammonium chloride; zinc; In methanol; at 80 ℃; for 24h;

DOI:10.1021/ja806585m

upstream raw materials:

2,2,6,6-tetramethyl-piperidine-N-oxyl

N-tosyl-(2,2-dimethyl)-pent-4-enylamine

Downstream raw materials:

(S)-(+)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol