1-Boc-2,5-diMethyl-piperazine

Base Information

• Chemical Name: 1-Boc-2,5-diMethyl-piperazine
• CAS No.: 643041-20-7
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.308
• Hs Code.: 2933599090
• Mol file: 643041-20-7.mol

Synonyms:1-Boc-2,5-diMethyl-piperazine;tert-Butyl 2,5-diMethylpiperazine-1-carboxylate;1-tert-Butoxycarbonyl-2,5-dimethylpiperazine

Chemical Property of 1-Boc-2,5-diMethyl-piperazine

Chemical Property:

• PSA: 41.57000
• LogP: 1.87040
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2,5-Dimethylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-2,5-diMethyl-piperazine

There total 24 articles about 1-Boc-2,5-diMethyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-01-0) → (2R,5S)-2,5-dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (309915-46-6,194032-41-2,194032-43-4,643041-20-7)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; In methanol; at 20 ℃; for 48h; under 2068.65 Torr;

Reference yield: 100.0%

4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-00-9) → (2R,5S)-2,5-dimethyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (309915-46-6,194032-41-2,194032-43-4,643041-20-7)

Guidance literature:

With formic acid; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 100.0%

(2S,5R)-tert-butyl 4-benzyl-2,5-dimethylpiperazine-1-carboxylate → (2S,5R)-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (548762-66-9,194032-41-2,194032-43-4,643041-20-7)

Guidance literature:

With formic acid; palladium on carbon; In methanol; at 20 ℃; Inert atmosphere; Cooling with ice;

upstream raw materials:

(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

di-tert-butyl dicarbonate

(+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine

2,5-dimethyl-piperazine

Downstream raw materials:

1-benzhydryl-2S,5R-dimethyl-piperazine

4-((S)-2-(3-(2-((2S,5R)-4-(tert-butoxycarbonyl)-2,5-dimethylpiperazin-1-yl)acetamido)-4-methoxybenzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

4-((S)-2-(3-(3-((2S,5R)-4-(tert-butoxycarbonyl)-2,5-dimethylpiperazin-1-yl)-3-oxopropanamido)-4-methoxybenzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

4-((S)-2-(4-(N-(3-((2S,5R)-4-(tert-butoxycarbonyl)-2,5-dimethylpiperazin-1-yl)propyl)methylsulfonamido)-3-(cyclopropylmethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

Refernces

• 1、 -. "MANUFACTURING METHOD OF OPTICALLY ACTIVE CARBINOL COMPOUND". Paragraph 0108; 0124. . Retrieved 2016/11/14.
• 2、 Tan, Xuefei,Tester, Richland W.,Luedtke, Gregory R.,Chakravarty, Sarvajit,Mavunkel, Babu J.,Perumattam, John J.,Lu, Qing,Nashashibi, Imad,Jung, Joon,Hu, Jie,Liclican, Albert,Almirez, Ramona,Tabora, Jocelyn,Tran, Vinh,Laney, Maureen,Levy, Daniel E.,Dugar, Sundeep. "Design and synthesis of piperazine-indole p38α MAP kinase inhibitors with improved pharmacokinetic profiles". scheme or table. p. 828 - 831. Retrieved 2010/06/13.