(4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester

Base Information

Chemical Name:(4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester
CAS No.:22882-57-1
Molecular Formula:C20H24O6
Molecular Weight:360.40096
Hs Code.:
Mol file:22882-57-1.mol

Synonyms:(4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester

Suppliers and Price of (4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester

Chemical Property:

Melting Point:133 - 135 °C
PSA：85.36000
LogP:1.35590

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester

There total 10 articles about (4bα)-2β,3β-Epoxy-7-hydroxy-1α,4aα-(carbonyloxy)-1-methyl-8-methylenegibbane-10β-carboxylic acid 10-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₃₀O₇Si

: 2065-66-9
methyl-triphenylphosphonium iodide

: 22882-57-1
ent-10β,13-dihydroxy-2α,3α-epoxy-20-norgibberell-16-ene-7,19-dioic acid 7-methyl ester 19,10-lactone

Guidance literature:: methyl-triphenylphosphonium iodide; With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at -78 - 20 ℃;

C₂₂H₃₀O₇Si; In tetrahydrofuran; tert-butyl alcohol; for 2.83333h;
DOI:10.1071/CH10441

Reference yield:

: 67-56-1
methanol

: C₂₃H₃₂O₈Si

: 2065-66-9
methyl-triphenylphosphonium iodide

: 22882-57-1
ent-10β,13-dihydroxy-2α,3α-epoxy-20-norgibberell-16-ene-7,19-dioic acid 7-methyl ester 19,10-lactone

Guidance literature:: methyl-triphenylphosphonium iodide; With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at -78 - 20 ℃;

C₂₃H₃₂O₈Si; In tetrahydrofuran; tert-butyl alcohol; for 2.83333h;

methanol; With pyridinium p-toluenesulfonate; for 0.416667h;
DOI:10.1071/CH10441

Reference yield:

: 1309586-73-9
C₂₂H₂₆O₈

: 22882-57-1
ent-10β,13-dihydroxy-2α,3α-epoxy-20-norgibberell-16-ene-7,19-dioic acid 7-methyl ester 19,10-lactone

Guidance literature:: Multi-step reaction with 4 steps

1.1: Oxone; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate / water; acetonitrile / 15 h / 0 °C

2.1: water; potassium carbonate / tetrahydrofuran; ethanol / 20 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / -78 - 20 °C

4.2: 2.83 h

4.3: 0.42 h

With Oxone; 1,1,1-trifluoro-2-propanone; potassium tert-butylate; water; edetate disodium; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; tert-butyl alcohol; 4.1: Wittig reaction / 4.2: Wittig reaction;
DOI:10.1071/CH10441