CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino][[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]Methylene]-, 1,1-diMethylethyl ester, [N(Z)]-

Base Information

Chemical Name:CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino][[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]Methylene]-, 1,1-diMethylethyl ester, [N(Z)]-
CAS No.:1143571-96-3
Molecular Formula:C23H36N4O5
Molecular Weight:448.563
Hs Code.:
Mol file:1143571-96-3.mol

Synonyms:CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino][[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]Methylene]-, 1,1-diMethylethyl ester, [N(Z)]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino][[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]Methylene]-, 1,1-diMethylethyl ester, [N(Z)]-

Chemical Property:

PSA：104.98000
LogP:4.60420

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino][[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]Methylene]-, 1,1-diMethylethyl ester, [N(Z)]-

There total 1 articles about CarbaMic acid, N-[[[(1,1-diMethylethoxy)carbonyl]aMino][[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]Methylene]-, 1,1-diMethylethyl ester, [N(Z)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 50609-01-3
4-(2-pyrrolidinoethoxy)aniline

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: 1143571-96-3
tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}methylidene]carbamate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield: 52.0%

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 1143571-96-3
tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}methylidene]carbamate

: 1142945-82-1
2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}methylidene]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h;

ethyl 2-cyano-4,4-diethoxybutyrate; With sodium methylate; In methanol; ethanol; at 160 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; ammonium hydroxide; more than 3 stages;

Reference yield:

: 1143571-96-3
tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}methylidene]carbamate

: 1147015-03-9
1-isopropyl-7-((2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

1.2: 0.5 h / 160 °C / Microwave irradiation

2.1: trichlorophosphate / 0.33 h / 120 °C

2.2: 0 °C / pH 9 - 10

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.58 h / 80 °C

With triethylamine; trifluoroacetic acid; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;