4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Chemical Name:4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:1147015-00-6
Molecular Formula:C₂₉H₃₁N₅O
Molecular Weight:465.598
Hs Code.:

Synonyms:4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Chemical Property of 4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Technology Process of 4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 7 articles about 4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1142945-83-2
⁽⁰⁸¹⁾C₀₇₅₀₄

: 75659-50-6
1-ethynyl-2-(1-methylethyl)benzene

: 1147015-00-6
4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 0.416667h;

Reference yield:

: 50609-01-3
4-(2-pyrrolidinoethoxy)aniline

: 1147015-00-6
4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 17 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

2.2: 0.5 h / 160 °C / Microwave irradiation

3.1: trichlorophosphate / 0.33 h / 120 °C

3.2: 0 °C / pH 9 - 10

4.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.42 h / 80 °C

With triethylamine; trifluoroacetic acid; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1142945-82-1
2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

: 1147015-00-6
4-((2-isopropylphenyl)ethynyl)-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.33 h / 120 °C

1.2: 0 °C / pH 9 - 10

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 0.42 h / 80 °C

With triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;