4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-

Base Information

Chemical Name:4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-
CAS No.:1142945-82-1
Molecular Formula:C18H21N5O2
Molecular Weight:339.397
Hs Code.:2933990090
Mol file:1142945-82-1.mol

Synonyms:4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-

Suppliers and Price of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,7-Dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one
10mg
$ 130.00

Chemenu
2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 95%
1g
$ 729.00

American Custom Chemicals Corporation
2-(4-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL 95.00%
5MG
$ 505.78

Total 5 raw suppliers

Chemical Property of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-

Chemical Property:

PSA：86.30000
LogP:2.89260
Storage Temp.:2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,7-Dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3,7-Dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one is a reactant used in the preparation of pyrrolopyrimidine compounds as janus kinase inhibitors with potential uses in the treatment of cancer.

Technology Process of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-

There total 2 articles about 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 1143571-96-3
tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}methylidene]carbamate

: 1142945-82-1
2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}methylidene]carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h;

ethyl 2-cyano-4,4-diethoxybutyrate; With sodium methylate; In methanol; ethanol; at 160 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; ammonium hydroxide; more than 3 stages;

Reference yield:

: 50609-01-3
4-(2-pyrrolidinoethoxy)aniline

: 1142945-82-1
2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 17 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

2.2: 0.5 h / 160 °C / Microwave irradiation

With trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 95.0%

: 1142945-82-1
2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

: 1142945-83-2
⁽⁰⁸¹⁾C₀₇₅₀₄

Guidance literature:: 2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol; With trichlorophosphate; at 120 ℃; for 0.333333h;

at 0 ℃; pH=9 - 10; Alkaline aqueous solution;