Telinavir

Base Information

Chemical Name:Telinavir
CAS No.:143224-34-4
Molecular Formula:C₃₃H₄₄N₆O₅
Molecular Weight:604.75
Hs Code.:
Mol file:143224-34-4.mol

Synonyms:Butanediamide,N1-[3-[[[(1,1-dimethylethyl)amino]carbonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-,[1S-[1R*(R*),2S*]]-; Compound E; SC 52151; Telinavir

Suppliers and Price of Telinavir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TELINAVIR 95.00%
5MG
$ 496.06

Total 2 raw suppliers

Chemical Property of Telinavir

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:974.9°Cat760mmHg
Flash Point:543.4°C
PSA：166.75000
Density:1.207g/cm³
LogP:4.63610

Purity/Quality:

97% ^*data from raw suppliers

TELINAVIR 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Antiviral.

Technology Process of Telinavir

There total 18 articles about Telinavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: [1S-[1R*(R*),2S*]]-N₁[3-[[[(1,1-dimethylethyl)amino]carbonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl-2-amino]butanediamide

: 136465-99-1
2,5-dioxopyrrolidin-1-ylquinoline-2-carboxylate

: 143224-34-4
[1S-[1R*(R*),2S*]]-N₁[3-[[[(1,1-dimethylethyl)amino]carbonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield: 43.0%

: 143224-34-4
[1S-[1R*(R*),2S*]]-N₁[3-[[[(1,1-dimethylethyl)amino]carbonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide

: 128018-43-9
N-benzyloxycarbonyl-3(S)-amino-1-chloro-4-phenyl-2(S)-butanol

Guidance literature:

Reference yield:

: 103127-52-2,107202-43-7
((S)-1-benzylallyl)carbamic acid tert-butyl ester

: 143224-34-4
(S)-N¹-[(1S,2S)-1-Benzyl-3-(3-tert-butyl-1-isobutyl-ureido)-2-hydroxy-propyl]-2-[(quinoline-2-carbonyl)-amino]-succinamide

Guidance literature:: Multi-step reaction with 7 steps

1: m-chloroperbenzoic acid (MCPBA)

2: propan-2-ol / Heating

3: CH₂Cl₂ / Ambient temperature

4: 4 N HCl / dioxane

5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole hydrate (HOBT) / dimethylformamide

6: H₂ / Pd(C) / ethanol

7: dimethylformamide

With hydrogenchloride; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm00054a014