1,1-Difluoro-2-phenylpropan-2-ol 97%

Base Information

• Chemical Name: 1,1-Difluoro-2-phenylpropan-2-ol 97%
• CAS No.: 432-88-2
• Molecular Formula: C9H10F2O
• Molecular Weight: 172.175
• Hs Code.: 2906290090
• Mol file: 432-88-2.mol

Synonyms:1,1-Difluoro-2-phenylpropan-2-ol 97%;1,1-Difluoro-2-phenylpropan-2-ol97%

Chemical Property of 1,1-Difluoro-2-phenylpropan-2-ol 97%

Chemical Property:

• Boiling Point: 81 °C(Press: 7 Torr)
• PKA: 12.26±0.29(Predicted)
• PSA: 20.23000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 2.15920

Purity/Quality:

98%min ^*data from raw suppliers

1,1-Difluoro-2-phenylpropan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-Difluoro-2-phenylpropan-2-ol 97%

There total 9 articles about 1,1-Difluoro-2-phenylpropan-2-ol 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,1-difluoro-2-phenyl-1-(phenylsulfonyl)propan-2-ol (861721-54-2) → 1,1-difluoro-2-phenyl propan-2-ol (432-88-2)

Guidance literature:

With magnesium; In water; N,N-dimethyl-formamide; at 20 ℃; for 4h; Solvent;

DOI:10.1016/j.jfluchem.2015.07.008

Reference yield: 82.0%

diethyl 1,1-difluoro-2-hydroxy-2-phenylpropylphosphonate (1093490-29-9) → 1,1-difluoro-2-phenyl propan-2-ol (432-88-2)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at 40 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.006

Reference yield:

acetophenone (98-86-2) → 1,1-difluoro-2-phenyl propan-2-ol (432-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: LHMDS; HMPA / tetrahydrofuran / -78 °C

2: Na₂HPO₄; Na/Hg amalgam / methanol / -20 - 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium amalgam; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2006.07.079

upstream raw materials:

1,1-difluoroacetone

1-(3,3-difluoroprop-1-en-2-yl)-2-methylbenzene

methyllithium

1,1-difluoro-2-phenyl-1-(phenylsulfonyl)propan-2-ol

Downstream raw materials:

α-(difluoromethyl)styrene

Refernces

• 1、 Walkowiak-Kulikowska, Justyna,Kanigowska, Joanna,Koroniak, Henryk. "α-(Difluoromethyl)styrene: Improved approach to grams scale synthesis". . p. 175 - 178. Retrieved 2015/11/10.
• 2、 Liu, Jun,Ni, Chuanfa,Li, Ya,Zhang, Laijun,Wang, Guanyu,Hu, Jinbo. "Facile preparation of difluoromethyl- and monofluoromethyl-containing amides via Ritter reaction". . p. 6753 - 6756. Retrieved 2007/10/03.