4-BROMOPHENYL-2'-NAPHTHYL KETONE

Base Information

• Chemical Name: 4-BROMOPHENYL-2'-NAPHTHYL KETONE
• CAS No.: 760192-88-9
• Molecular Formula: C17H11BrO
• Molecular Weight: 311.178
• Hs Code.: 2914700090
• Mol file: 760192-88-9.mol

Synonyms:4-BROMOPHENYL-2'-NAPHTHYL KETONE

Chemical Property of 4-BROMOPHENYL-2'-NAPHTHYL KETONE

Chemical Property:

• Vapor Pressure: 5.23E-08mmHg at 25°C
• Boiling Point: 441.9°C at 760 mmHg
• Flash Point: 89.8°C
• PSA: 17.07000
• Density: 1.428g/cm³
• LogP: 4.83330

Purity/Quality:

97% ^*data from raw suppliers

4-bromophenyl-2'-naphthylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMOPHENYL-2'-NAPHTHYL KETONE

There total 2 articles about 4-BROMOPHENYL-2'-NAPHTHYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.7%

2-bromonaphthalene (580-13-2) + 4-chlorobenzoyl chloride (586-75-4) → (4-bromophenyl) (naphthalen-2-yl)methanone (760192-88-9)

Guidance literature:

2-bromonaphthalene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

4-chlorobenzoyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.dyepig.2019.108041

Reference yield: 21.0%

4-bromo-benzaldehyde (1122-91-4) + 1-(trimethylsilyl)naphthalen-2-yl triflate (252054-88-9) → (4-bromophenyl)(naphthalen-1-yl)methanone (1096920-53-4) + (4-bromophenyl) (naphthalen-2-yl)methanone (760192-88-9)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; potassium tert-butylate; In tetrahydrofuran; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201005490

Reference yield: 73.0%

(4-bromophenyl) (naphthalen-2-yl)methanone (760192-88-9) + pivaloyl chloride (3282-30-2) → C22H20BrNO2

Guidance literature:

(4-bromophenyl) (naphthalen-2-yl)methanone; With hydroxylamine hydrochloride; potassium acetate; In methanol; at 60 ℃; for 0.5h;

pivaloyl chloride; With triethylamine; at 0 - 20 ℃; for 0.5h;

upstream raw materials:

4-bromo-benzaldehyde

1-(trimethylsilyl)naphthalen-2-yl triflate

2-bromonaphthalene

4-chlorobenzoyl chloride

Refernces

• 1、 Biju, Akkattu T.,Glorius, Frank. "Intermolecular N-heterocyclic carbene catalyzed hydroacylation of arynes". supporting information; experimental part. p. 9761 - 9764. Retrieved 2011/03/16.