1-PIPERAZINECARBOXYLIC ACID,4-FORMYL-,1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: 1-PIPERAZINECARBOXYLIC ACID,4-FORMYL-,1,1-DIMETHYLETHYL ESTER
• CAS No.: 183383-30-4
• Molecular Formula: C10H18N2O3
• Molecular Weight: 214.26
• Mol file: 183383-30-4.mol

Synonyms:1-PIPERAZINECARBOXYLIC ACID,4-FORMYL-,1,1-DIMETHYLETHYL ESTER;Tert-butyl 4-formylpiperazine-1-carboxylate

Chemical Property of 1-PIPERAZINECARBOXYLIC ACID,4-FORMYL-,1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 49.85000
• LogP: 1.20720

Purity/Quality:

99% ^*data from raw suppliers

1-PIPERAZINECARBOXYLICACID,4-FORMYL-,1,1-DIMETHYLETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PIPERAZINECARBOXYLIC ACID,4-FORMYL-,1,1-DIMETHYLETHYL ESTER

There total 9 articles about 1-PIPERAZINECARBOXYLIC ACID,4-FORMYL-,1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloroform (67-66-3,8013-54-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-formylpiperazine-1-carboxylate (183383-30-4)

Guidance literature:

With sodium ethanolate; at 50 ℃; Inert atmosphere;

DOI:10.1080/00397910903576644

Reference yield: 95.0%

carbon dioxide (124-38-9,18923-20-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-formylpiperazine-1-carboxylate (183383-30-4)

Guidance literature:

With sodium tetrahydroborate; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

DOI:10.1039/d1ra04848a

Reference yield: 89.0%

tert-butyl 4-((trimethylsilyl)methyl)piperazine-1-carboxylate → tert-butyl 4-formylpiperazine-1-carboxylate (183383-30-4)

Guidance literature:

With copper(I) bromide; In acetonitrile; at 25 ℃; for 4h; chemoselective reaction;

DOI:10.1039/d0gc01242d

upstream raw materials:

piperazine-1-carbaldehyde

di-tert-butyl dicarbonate

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

chloroform

Downstream raw materials:

tert-butyl 4-methylpiperazine-1-carboxylate

1-[(4-chlorophenyl)phenylmethyl]-4-(tert-butoxycarbonyl)-piperazine