4-CYANO-4,4-DIPHENYLBUTANOIC ACID

Base Information

• Chemical Name: 4-CYANO-4,4-DIPHENYLBUTANOIC ACID
• CAS No.: 6523-63-3
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol file: 6523-63-3.mol

Synonyms:4-CYANO-4,4-DIPHENYLBUTANOIC ACID

Chemical Property of 4-CYANO-4,4-DIPHENYLBUTANOIC ACID

Chemical Property:

Purity/Quality:

4-CYANO-4,4-DIPHENYLBUTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-CYANO-4,4-DIPHENYLBUTANOIC ACID

There total 7 articles about 4-CYANO-4,4-DIPHENYLBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-butyl 4-cyano-4,4-diphenylbutanoate (931409-69-7) → 4-cyano-4,4-diphenylbutanoic acid (6523-63-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

Diphenylacetonitrile (86-29-3) → 4-cyano-4,4-diphenylbutanoic acid (6523-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; tert-butyl alcohol / 23 h / 20 - 50 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium hydroxide; In 1,4-dioxane; methanol; tert-butyl alcohol;

DOI:10.1021/jm200884j

Reference yield:

4-cyano-4,4-diphenyl-butyric acid ethyl ester (2997-23-1) → 4-cyano-4,4-diphenylbutanoic acid (6523-63-3)

Guidance literature:

With alkaline solution;

upstream raw materials:

ethyl 3-iodopropanoate

Diphenylacetonitrile

4-cyano-4,4-diphenyl-butyric acid ethyl ester

acrylic acid methyl ester

Downstream raw materials:

2,2-diphenylpentanedioic acid

4-cyano-4,4-diphenylbutanoyl chloride

3,3-diphenyl-piperidine-2,6-dione

4-oxo-1-phenyl-1,2,3,4-tetrahydro-1-naphthalenecarboxamide