Technology Process of tert-butyl 4-cyano-4,4-diphenylbutanoate
There total 1 articles about tert-butyl 4-cyano-4,4-diphenylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol; tert-butyl alcohol;
at 20 - 60 ℃;
for 23.5h;
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
2.1: dmap / propiononitrile / 0.17 h / 20 °C / Large scale reaction
2.2: 20 °C / Large scale reaction
3.1: zirconium(IV) chloride / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Large scale reaction
3.2: -5 - 0 °C / Inert atmosphere; Large scale reaction
4.1: methanesulfonic acid / 0.5 h / 20 °C / Large scale reaction
4.2: 72 h / 30 °C / Large scale reaction
5.1: potassium hydroxide / tert-Amyl alcohol / 24 h / 80 - 99 °C / Large scale reaction
5.2: 19 h / 20 °C / Large scale reaction
With
hydrogenchloride; dmap; methanesulfonic acid; zirconium(IV) chloride; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; tert-Amyl alcohol; propiononitrile;
DOI:10.1021/op200233r
