tert-butyl 4-cyano-4,4-diphenylbutanoate

Base Information

Chemical Name:tert-butyl 4-cyano-4,4-diphenylbutanoate
CAS No.:931409-69-7
Molecular Formula:C₂₁H₂₃NO₂
Molecular Weight:321.419
Hs Code.:

Synonyms:tert-butyl 4-cyano-4,4-diphenylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-cyano-4,4-diphenylbutanoate

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Technology Process of tert-butyl 4-cyano-4,4-diphenylbutanoate

There total 1 articles about tert-butyl 4-cyano-4,4-diphenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 86-29-3
Diphenylacetonitrile

: 931409-69-7
tert-butyl 4-cyano-4,4-diphenylbutanoate

Guidance literature:: With potassium hydroxide; In methanol; tert-butyl alcohol; at 20 - 60 ℃; for 23.5h;

Reference yield: 77.0%

: 931409-69-7
tert-butyl 4-cyano-4,4-diphenylbutanoate

: 6523-63-3
4-cyano-4,4-diphenylbutanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 931409-69-7
tert-butyl 4-cyano-4,4-diphenylbutanoate

: 1079781-31-9
5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2 diphenyl hexanamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

2.1: dmap / propiononitrile / 0.17 h / 20 °C / Large scale reaction

2.2: 20 °C / Large scale reaction

3.1: zirconium(IV) chloride / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Large scale reaction

3.2: -5 - 0 °C / Inert atmosphere; Large scale reaction

4.1: methanesulfonic acid / 0.5 h / 20 °C / Large scale reaction

4.2: 72 h / 30 °C / Large scale reaction

5.1: potassium hydroxide / tert-Amyl alcohol / 24 h / 80 - 99 °C / Large scale reaction

5.2: 19 h / 20 °C / Large scale reaction

With hydrogenchloride; dmap; methanesulfonic acid; zirconium(IV) chloride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; tert-Amyl alcohol; propiononitrile;
DOI:10.1021/op200233r