2997-23-1Relevant academic research and scientific papers
Condensed heterocyclic compounds, their production and use
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, (2008/06/13)
The compound STR1 wherein ring A represents a benzene ring; Ar represents an aromatic group; R 1 and R 2 independently represent hydrogen, acyl or hydrocarbon group or R 1 and R 2 taken together with the adjacent nitrogen atom represent a nitrogen-contain
Amine compounds, their production and use
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, (2008/06/13)
A compound of the formula: STR1 wherein Ar 1 and Ar 2 independently represent an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydrocarbon group having at least 2 carbon atoms and optionally having either oxygen or sulfur in the carbon chain; R 1 and R 3 independently represent --CO--R, --CONH--R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R 2 and R 4 independently represent hydrogen or an alkyl group; R 2 and R 4 independently represent hydrogen or an alkyl group; R 1 and R 2 or R 3 and R 4, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof, has excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.
Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties
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, (2008/06/13)
Compounds of the formula I, STR1 wherein R1, R2, R3 and R4 independently represent hydrogen, alkyl, phenyl or substituted phenyl with the proviso that two of R1, R2, R3 or R4 are phenyl or substituted phenyl and two of R1, R2, R3 or R4 are hydrogen or alkyl; m represents an integer from 1-2; and n represents an integer from 1-3; or a pharmaceutically acceptable salt thereof. The compounds are useful as pharmaceuticals, in particular, in the treatment of epilepsy.
