17-PA

Base Information

• Chemical Name: 17-PA
• CAS No.: 694438-95-4
• Molecular Formula: C₂₅H₃₄O
• Molecular Weight: 350.544
• Mol file: 694438-95-4.mol

Synonyms:17-PA;17-PHENYL-(3A,5A)-ANDROST-16-EN-3-OL;17-Phenyl-(3α,5α)-androst-16-en-3-ol

Chemical Property of 17-PA

Chemical Property:

• Vapor Pressure: 9.47E-10mmHg at 25°C
• Boiling Point: 472.9°C at 760 mmHg
• Flash Point: 197.4°C
• PSA: 20.23000
• Density: 1.073g/cm³
• LogP: 6.08350
• Storage Temp.: Store at RT

Purity/Quality:

≥99% by HPLC ^*data from raw suppliers

17-PA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 17-PA is an antagonist of neurosteroid GABA potentiation.

Technology Process of 17-PA

There total 9 articles about 17-PA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3α-methoxymethoxy-17-phenyl-5α-androst-16-ene (1135993-41-7) → 3alpha,5alpha-17-Phenylandrost-16-en-3-ol (694438-95-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

DOI:10.3184/030823408X333409

Reference yield: 95.0%

(3α,5α)-17-phenylandrost-16-en-3-ol acetate (694438-98-7) → 3alpha,5alpha-17-Phenylandrost-16-en-3-ol (694438-95-4)

Guidance literature:

With sodium hydroxide; water; In methanol; for 1h; Heating;

DOI:10.1124/mol.65.5.1191

Reference yield: 65.0%

17-iodo-3β-hydroxy-5α-androstan-16-ene (95043-81-5) + phenylboronic acid (98-80-6) → (3β,5α)-17-phenylandrost-16-en-3-ol (694438-95-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; water; benzene; for 24h; Schlenk technique; Reflux;

DOI:10.1002/adsc.201601289

upstream raw materials:

(3α,5α)-17-phenylandrost-16-en-3-ol acetate

(3α,5α,17β)-17-phenylandrostane-3,17-diol

(3α,5α,17β)-17-phenylandrostane-3,17-diol-3-acetate

cis-androsterone