Nilotinib Hydrochloride

Base Information Edit

Chemical Name:Nilotinib Hydrochloride
CAS No.:923288-95-3
Molecular Formula:C₂₈H₂₂F₃N₇O*2ClH
Molecular Weight:602.446
Hs Code.:
European Community (EC) Number:810-280-3
UNII:K37N7BYX3X
DSSTox Substance ID:DTXSID60238968
NCI Thesaurus Code:C95223
Wikidata:Q27281888
Mol file:923288-95-3.mol

Synonyms:4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide;AMN 107;AMN-107;AMN107;benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride (1:1);benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate;benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate (1:1:2);benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate (1:2:2);benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-, hydrochloride, hydrate (2:2:3);nilotinib;nilotinib dihydrochloride dihydrate;nilotinib hydrochloride;nilotinib hydrochloride anhydrous;nilotinib hydrochloride dihydrate;nilotinib hydrochloride hydrate;nilotinib hydrochloride monohydrate;nilotinib hydrochloride sesquihydrate;Tasigna

Suppliers and Price of Nilotinib Hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NilotinibHydrochloride
250mg
$ 205.00

Axon Medchem
Nilotinibhydrochloride-AMN107hydrochloride 99%
50 mg
$ 154.00

Axon Medchem
Nilotinibhydrochloride-AMN107hydrochloride 99%
10 mg
$ 77.00

American Custom Chemicals Corporation
NILOTINIB HYDROCHLORIDE 95.00%
5MG
$ 452.67

Total 14 raw suppliers

Chemical Property of Nilotinib Hydrochloride Edit

Chemical Property:

PSA：101.11000
LogP:7.61480
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:565.1604706
Heavy Atom Count:40
Complexity:817

Purity/Quality:

98%,99%, ^*data from raw suppliers

NilotinibHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.Cl
Recent ClinicalTrials:Effect of Calcium on Tasigna Pharmacokinetics (PK) in Healthy Volunteers
Recent EU Clinical Trials:An open-label, multi-center, single-arm study to evaluate the efficacy of nilotinib in adult patients with metastatic or unresectable gastrointestinal stromal tumors in first line treatment
Uses Nilotinib Hydrochloride might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.

Technology Process of Nilotinib Hydrochloride

There total 9 articles about Nilotinib Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%