4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

Base Information

Chemical Name:4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide
CAS No.:1345336-53-9
Molecular Formula:C₂₀H₁₉F₃N₆O
Molecular Weight:416.406
Hs Code.:

Synonyms:4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

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Technology Process of 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

There total 13 articles about 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 915711-42-1
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-aminobenzamide

: 420-04-2
CYANAMID

: 1345336-53-9
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

Guidance literature:: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-aminobenzamide; CYANAMID; With hydrogenchloride; In water; butan-1-ol; at 90 - 95 ℃; for 20h; pH=2-3;

With sodium hydroxide; In water; butan-1-ol; at 20 ℃; for 2h;
DOI:10.14233/ajchem.2013.14247

Reference yield: 88.0%

: 3-guanidino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide hydrochloride

: 1345336-53-9
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

Guidance literature:: With ammonia;

Reference yield:

: 41191-92-8
3-amino-4-methylbenzoic acid ethyl ester

: 1345336-53-9
4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-guanidinobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 55 - 60 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / -10 - -5 °C

3: hydrogenchloride / butan-1-ol; water / 90 - 100 °C

4: butan-1-ol; water / 90 - 100 °C

5: ammonia

With hydrogenchloride; potassium tert-butylate; ammonia; In dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;