ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

Base Information

Chemical Name:ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate
CAS No.:1272355-42-6
Molecular Formula:C26H21N5O2S
Molecular Weight:467.551
Hs Code.:
Mol file:1272355-42-6.mol

Synonyms:ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

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Chemical Property of ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

Chemical Property:

PSA：118.13000
LogP:5.67710

Purity/Quality:

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Technology Process of ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

There total 8 articles about ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 928716-12-5
ethyl thiooxamate

: 1272357-20-6
2-bromo-1-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)ethanone

: 1272355-42-6
ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

Guidance literature:: In ethanol; at 70 ℃; for 1h;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272355-42-6
ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3: triethylamine / tetrahydrofuran / 14 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

5: N-Bromosuccinimide / 1,4-dioxane; water / 0.33 h / 0 - 20 °C

6: ethanol / 1 h / 70 °C

With N-Bromosuccinimide; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water;

Reference yield:

: 20780-72-7
4-bromoisatin

: 1272355-42-6
ethyl 4-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)thiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C

1.2: pH 4 - 5

2.1: acetic acid / water / 35 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

5.1: triethylamine / tetrahydrofuran / 14 h / 20 °C

6.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

7.1: N-Bromosuccinimide / 1,4-dioxane; water / 0.33 h / 0 - 20 °C

8.1: ethanol / 1 h / 70 °C

With N-Bromosuccinimide; dihydrogen peroxide; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water;